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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

480415 Sigma-AldrichNF023 - Calbiochem

A suramin analog that acts as a selective and direct G-protein antagonist for α-subunits of the Go/Gi group (EC₅₀ ~ 300 nM).

NF023 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 8,8ʹ-[Carbonylbis(imino-3,1-phenylene)]bis-(1,3,5-naphthalenetrisulfonic Acid), 6Na, P2X Antagonist I, Purinergic Receptor P2X Antagonist I

Primary Target: α-subunits of the Go/Gi group of G-protein

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概述

Replacement Information

重要规格表

Empirical Formula
C₃₅H₂₀N₄O₂₁S₆ · 6Na

价格及供货情况

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Description
Overview	A suramin analog that acts as a selective and direct G-protein antagonist for α-subunits of the G_o/G_i group (EC₅₀ ~ 300 nM). Suppresses GTPγS binding to recombinant G-protein α-subunits. Acts by inhibiting the formation of the agonist-specific ternary complex (agonist/receptor/G-protein). NF023 does not interfere with the interaction between α-subunits and βγ-dimer but competes with the effector binding site. Also a P2X receptor antagonist (IC₅₀ = 240 nM for P2X1; 8.5 µM for P2X3 receptor in rat muscle). Causes a concentration dependent inhibition of excitatory junction potentials (IC₅₀ = 4.8 pM).
Catalogue Number	480415
Brand Family	Calbiochem®
Synonyms	8,8ʹ-[Carbonylbis(imino-3,1-phenylene)]bis-(1,3,5-naphthalenetrisulfonic Acid), 6Na, P2X Antagonist I, Purinergic Receptor P2X Antagonist I

References
References	Snedden, P., et al. 2000. Br. J. Pharmacol. 129, 1089. Soto, F., et al. 1999. Neuropharmacology 38, 141. Beindle, W., et al. 1996. Mol. Pharmacol. 50, 415. Freissmuth, M., et al. 1996. Mol. Pharmacol. 49, 602.

Product Information
ATP Competitive	N
Form	White to off-white solid
Hill Formula	C₃₅H₂₀N₄O₂₁S₆ · 6Na
Chemical formula	C₃₅H₂₀N₄O₂₁S₆ · 6Na
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	α-subunits of the Go/Gi group of G-protein
Primary Target IC<sub>50</sub>	240 nM for P2X1; 8.5 µM for P2X3 receptor in rat muscle; 4.8 pM in the inhibition of excitatory junction potentials; EC50 ~ 300 nM as G-protein antagonist for α-subunits of the Go/Gi group
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
480415-10MGCN	04055977201345

Documentation

NF023 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

NF023 - Calbiochem 分析证书

标题	批号
480415	输入批号

参考

参考信息概述
Snedden, P., et al. 2000. Br. J. Pharmacol. 129, 1089. Soto, F., et al. 1999. Neuropharmacology 38, 141. Beindle, W., et al. 1996. Mol. Pharmacol. 50, 415. Freissmuth, M., et al. 1996. Mol. Pharmacol. 49, 602.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-June-2018 JSW
Synonyms	8,8ʹ-[Carbonylbis(imino-3,1-phenylene)]bis-(1,3,5-naphthalenetrisulfonic Acid), 6Na, P2X Antagonist I, Purinergic Receptor P2X Antagonist I
Description	A suramin analog that acts as a selective G-protein antagonist for α-subunits of the G_o/G_i group (EC₅₀ ~300 nM). Suppresses GTPγS binding to recombinant G-protein α-subunits. Acts by inhibiting the formation of the agonist-specific ternary complex (agonist/receptor/G-protein). NF023 does not interfere with the interaction between α-subunits βγ-dimer but competes with the effector binding site. Also a P2X receptor antagonist (IC₅₀=0.24 µM for P2X1; 8.5 µM for P2X3 receptor in rat muscle).
Form	White to off-white solid
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₃₅H₂₀N₄O₂₁S₆ · 6Na
Structure formula
Purity	≥95% by HPLC
Solubility	H₂O
Storage	+2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
Toxicity	Standard Handling
References	Snedden, P., et al. 2000. Br. J. Pharmacol. 129, 1089. Soto, F., et al. 1999. Neuropharmacology 38, 141. Beindle, W., et al. 1996. Mol. Pharmacol. 50, 415. Freissmuth, M., et al. 1996. Mol. Pharmacol. 49, 602.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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