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481480 NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem

概述

重要规格表

Empirical Formula
C₁₂₉H₂₃₀N₃₆O₂₉S

价格及供货情况

产品目录编号 库存情况包装 数量 / 包装 价格 数量
481480-1MGCN
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      塑胶安瓿;塑胶针药瓶 1 mg
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      481480-500UGCN
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          塑胶安瓿;塑胶针药瓶 500 μg
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          Description
          OverviewContains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.
          Catalogue Number481480
          Brand Family Calbiochem®
          SynonymsAAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII
          References
          ReferencesLin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
          Product Information
          ATP CompetitiveN
          DeclarationSold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₂₉H₂₃₀N₃₆O₂₉S
          Chemical formulaC₁₂₉H₂₃₀N₃₆O₂₉S
          Hygroscopic Hygroscopic
          ReversibleN
          Sold on the basis of peptide contentY
          Quality LevelMQ100
          Biological Information
          Primary Targettranslocation of the NF-κB active complex into the nucleus
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide ContentY
          Peptide SequenceH-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
          Global Trade Item Number
          产品目录编号 GTIN
          481480-1MGCN 04055977183771
          481480-500UGCN 04055977183788