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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

481480 Sigma-AldrichNF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem

NF-κB SN50, CAS 213546-43-3, is a cell-permeable peptide that contains the NLS sequence of NF-κB p50 linked to the hydrophobic region of K-FGF. Inhibits translocation of the NF-κB into the nucleus.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

同义词: AAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII

Primary Target: translocation of the NF-κB active complex into the nucleus

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概述

Replacement Information

重要规格表

Empirical Formula
C₁₂₉H₂₃₀N₃₆O₂₉S

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
481480-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
481480-500UGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	500 μg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	Contains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.
Catalogue Number	481480
Brand Family	Calbiochem®
Synonyms	AAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII

References
References	Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.

Product Information
ATP Competitive	N
Declaration	Sold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.
Form	Lyophilized
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₁₂₉H₂₃₀N₃₆O₂₉S
Chemical formula	C₁₂₉H₂₃₀N₃₆O₂₉S
Hygroscopic	Hygroscopic
Reversible	N
Sold on the basis of peptide content	Y
Quality Level	MQ100

Applications

Biological Information
Primary Target	translocation of the NF-κB active complex into the nucleus
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Content	Y
Peptide Sequence	H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
481480-1MGCN	04055977183771
481480-500UGCN	04055977183788

Documentation

NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem 分析证书

标题	批号
481480	输入批号

参考

参考信息概述
Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.

小册子

标题
Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling

引用

标题

Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	03-March-2008 JSW
Synonyms	AAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII
Description	Contains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The peptide N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, inhibition of NF-κB nuclear translocation is maximally inhibited at 18 µM.
Form	Lyophilized
Formulation	Supplied as a trifluoroacetate salt.
Chemical formula	C₁₂₉H₂₃₀N₃₆O₂₉S
Peptide Sequence	H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
Purity	≥97% by HPLC
Solubility	H₂O (5 mg/ml)
Storage	-20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
Toxicity	Standard Handling
References	Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
Citation	Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > NF-κB Activation

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