Millipore Sigma Vibrant Logo

481408 NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem

NF-kB Activation Inhibitor II, JSH-23, CAS 749886-87-1, is a cell-permeable, selective inhibitor of nuclear translocation of NF-kB p65 and its transcription activity (IC50 = 7.1 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine

Primary Target: Blocks nuclear translocation of NF-κB p65 and its transcription activity
View Products on Sigmaaldrich.com
481408
查看价格及供货情况

概述

Replacement Information

重要规格表

CAS #Empirical Formula
749886-87-1C₁₆H₂₀N₂

价格及供货情况

产品目录编号 库存情况包装 数量 / 包装 价格 数量
481408-5MGCN
正在查询供货情况......
—
目前缺货 目前缺货
有货 
停产
少量现货
供货情况有待确认
    其余：另行通知
      其余：另行通知
      另行通知
      联系客户服务
      Contact Customer Service

      		 塑胶安瓿;塑胶针药瓶 5 mg
      正在检索价格......
      无法检索价格。
      最小订购数量为倍数
      Maximum Quantity is
      以订单确认为准 更多信息
      您节约了 ()。
       
      —
      Request Pricing
      		 —
      Description
      OverviewA cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC50 = 7.1 µM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.
      Catalogue Number481408
      Brand Family Calbiochem®
      Synonyms4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine
      References
      ReferencesShin, H.M., et al. 2004. FEBS Lett. 571, 50.
      Product Information
      CAS number749886-87-1
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₆H₂₀N₂
      Chemical formulaC₁₆H₂₀N₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationNF-kB Activation Inhibitor II, JSH-23, CAS 749886-87-1, is a cell-permeable, selective inhibitor of nuclear translocation of NF-kB p65 and its transcription activity (IC50 = 7.1 µM).
      Biological Information
      Primary TargetBlocks nuclear translocation of NF-κB p65 and its transcription activity
      Primary Target IC<sub>50</sub>7.1 µM in a NF-κB reporter assay using RAW 264.7
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      481408-5MGCN 07790788050672

      Documentation

      NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem 分析证书

      标题批号
      481408

      参考

      参考信息概述
      Shin, H.M., et al. 2004. FEBS Lett. 571, 50.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine
      DescriptionA cell-permeable, selective blocker of the nuclear translocation of NF-κB p65 that does not affect IκB degradation (IC50 = 7.1 µM in LPS-stimulated macrophages RAW 264.7 stably transfected with pNF-κB-SEAP-NPT). Shown to suppress DNA-binding of NF-κB and downregulate LPS-inducible expression of TNF-α, IL-1β, IL-6, iNOS, and COX-2. Also prevents LPS-induced apoptotic chromatin condensation.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number749886-87-1
      Chemical formulaC₁₆H₂₀N₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesShin, H.M., et al. 2004. FEBS Lett. 571, 50.