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480001
MilliporeNDSB-195 - CAS 160255-06-1 - Calbiochem
A non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins.
More>>A non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. Less<<
NDSB-195 - CAS 160255-06-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. Zwitterionic over a wide pH range. Does not absorb significantly in the near-UV range. Easily removed by dialysis.
Catalogue Number
480001
Brand Family
Calbiochem®
Synonyms
Dimethylethylammonium Propane Sulfonate
References
References
Goldberg, M.E., et al. 1996. Folding & Design 1, 21. Vuillard, L., et al. 1995. Anal. Biochem. 230, 290. Vuillard, L., et al. 1995. Biochem. J. 305, 337. Vuillard, L., et al. 1994. FEBS Lett.353, 294.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
13-April-2011 RFH
Synonyms
Dimethylethylammonium Propane Sulfonate
Description
A member of the class of nondetergent sulfobetaines. Unlike CHAPS and other zwittergents, NDSBs are nondenaturing even at 1 M concentrations. NDSBs have been used to improve the efficiency of solubilization of membrane proteins, to isolate nuclear proteins, to chromatographically purify halophilic proteins in low ionic strength buffers, and to crystallize proteins. They are zwitterionic over a wide pH range and do not absorb significantly in the near UV range. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. NDSBs can be easily removed by dialysis.
Form
White solid
CAS number
160255-06-1
Chemical formula
C₇H₁₇NO₃S
Structure formula
Purity
≥95% by TLC
Solubility
H₂O
Storage
+15°C to +30°C
Hygroscopic
Do Not Freeze
Ok to freeze
Toxicity
Irritant
References
Goldberg, M.E., et al. 1996. Folding & Design 1, 21. Vuillard, L., et al. 1995. Anal. Biochem. 230, 290. Vuillard, L., et al. 1995. Biochem. J. 305, 337. Vuillard, L., et al. 1994. FEBS Lett.353, 294.
