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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

616387 Sigma-AldrichN^α-Tosyl-Phe Chloromethyl Ketone

Irreversible inhibitor of chymotrypsin.

N^α-Tosyl-Phe Chloromethyl Ketone MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

同义词: TPCK

Primary Target: chymotrypsin activity in preparations

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
402-71-1	C₁₇H₁₈ClNO₃S

价格及供货情况

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Description
Overview	This product has been discontinued. Irreversible inhibitor of chymotrypsin. Useful for inhibiting chymotrypsin activity in trypsin preparations. Inhibits apoptosis in thymocytes. Blocks the induction of nitric oxide synthase by γ-interferon and lipopolysaccharides (EC₅₀ = 20 µM).
Catalogue Number	616387
Brand Family	Calbiochem®
Synonyms	TPCK

References
References	Fearnhead, H.O., et al. 1995. FEBS Lett. 357, 242. Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721. Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488. Murakami, T., et al. 1991. Biochim. Biophys. Acta 1079, 279. Nierodzik, M.L., et al. 1991. J. Clin. Invest. 87, 229. Wilson, W.E., et al. 1989. J. Biol. Chem. 264, 17777.

Product Information
CAS number	402-71-1
ATP Competitive	N
Form	White solid
Hill Formula	C₁₇H₁₈ClNO₃S
Chemical formula	C₁₇H₁₈ClNO₃S
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	chymotrypsin activity in preparations
Primary Target IC<sub>50</sub>	EC50 = 20 µM in blocking the induction of nitric oxide synthase by γ-interferon and lipopolysaccharides.
Purity	≥98% by TLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	XT5613500

Safety Information
R Phrase	R: 41 Risk of serious damage to eyes.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
616387-250MGCN	04055977186314

Documentation

N^α-Tosyl-Phe Chloromethyl Ketone MSDS

职位
物料安全数据表 (MSDS)

N^α-Tosyl-Phe Chloromethyl Ketone 分析证书

标题	批号
616387	输入批号

参考

参考信息概述
Fearnhead, H.O., et al. 1995. FEBS Lett. 357, 242. Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721. Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488. Murakami, T., et al. 1991. Biochim. Biophys. Acta 1079, 279. Nierodzik, M.L., et al. 1991. J. Clin. Invest. 87, 229. Wilson, W.E., et al. 1989. J. Biol. Chem. 264, 17777.

引用

标题

Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-September-2008 RFH
Synonyms	TPCK
Description	Irreversible inhibitor of chymotrypsin. Useful for inhibiting chymotrypsin activity in trypsin preparations. Inhibits apoptosis in thymocytes. Blocks the induction of nitric oxide synthase by γ-interferon and lipopolysaccharide (EC₅₀ = 20 µM). Suggested working concentration is 10-100 µM.
Form	White solid
CAS number	402-71-1
RTECS	XT5613500
Chemical formula	C₁₇H₁₈ClNO₃S
Structure formula
Purity	≥98% by TLC
Solubility	Ethanol (5 mg/ml) or Methanol (5 mg/ml)
Storage	+2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
Toxicity	Irritant
References	Fearnhead, H.O., et al. 1995. FEBS Lett. 357, 242. Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721. Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488. Murakami, T., et al. 1991. Biochim. Biophys. Acta 1079, 279. Nierodzik, M.L., et al. 1991. J. Clin. Invest. 87, 229. Wilson, W.E., et al. 1989. J. Biol. Chem. 264, 17777.
Citation	Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Sphingomyelinase Kinase Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors

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616387 Sigma-AldrichN^α-Tosyl-Phe Chloromethyl Ketone

Irreversible inhibitor of chymotrypsin.

同义词: TPCK

Recommended Products

概述

重要规格表

价格及供货情况

Documentation

N^α-Tosyl-Phe Chloromethyl Ketone MSDS

N^α-Tosyl-Phe Chloromethyl Ketone 分析证书

参考

引用

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Irreversible inhibitor of chymotrypsin.

同义词: TPCK

Recommended Products

重要规格表

价格及供货情况

Nα-Tosyl-Phe Chloromethyl Ketone MSDS

Nα-Tosyl-Phe Chloromethyl Ketone 分析证书

参考

引用

种类

最近查看的内容

N^α-Tosyl-Phe Chloromethyl Ketone MSDS

N^α-Tosyl-Phe Chloromethyl Ketone 分析证书