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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

616382 Sigma-AldrichN^α-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem

Inhibits trypsin-like serine proteinases.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

同义词: TLCK

Primary Target: trypsin like proteases

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Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
4238-41-9	C₁₄H₂₁ClN₂O₃S . HCl

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
616382-250MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	250 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
616382-50MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	50 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	Inhibits trypsin-like serine proteinases. Irreversibly inactivates trypsin without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to the target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC₅₀ = 80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemia cells and normal thymocytes.
Catalogue Number	616382
Brand Family	Calbiochem®
Synonyms	TLCK

References
References	Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721. Kim, H., et al. 1995. J. Immunol. 154, 4741. Bourinbaiar, A.S. and Nagorny, R. 1994. Cell Immunol. 155, 230. Biro, A., et al. 1992. Eur. J. Immunol. 22, 2547. Bruno, S., et al. 1992. Leukemia 6, 1113. Lee, S.F. 1992. Infect. Immun. 60, 4032. Schmidt, H.H., et al. 1992. Mol. Pharmacol. 41, 615.

References

Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
Kim, H., et al. 1995. J. Immunol. 154, 4741.
Bourinbaiar, A.S. and Nagorny, R. 1994. Cell Immunol. 155, 230.
Biro, A., et al. 1992. Eur. J. Immunol. 22, 2547.
Bruno, S., et al. 1992. Leukemia 6, 1113.
Lee, S.F. 1992. Infect. Immun. 60, 4032.
Schmidt, H.H., et al. 1992. Mol. Pharmacol. 41, 615.

Product Information
CAS number	4238-41-9
ATP Competitive	N
Form	Off-white solid
Hill Formula	C₁₄H₂₁ClN₂O₃S . HCl
Chemical formula	C₁₄H₂₁ClN₂O₃S . HCl
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	trypsin like proteases
Primary Target IC<sub>50</sub>	EC50 = 80 µM blocking nitric oxide synthase induced by interferon-γ and lipopolysaccharides in macrophages
Purity	≥95% by elemental analysis

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	XT5160000

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Unstable in solution; reconstitute just prior to use.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
616382-250MGCN	04055977186284
616382-50MGCN	04055977186291

Documentation

N^α-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

N^α-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem 分析证书

标题	批号
616382	输入批号

参考

参考信息概述
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721. Kim, H., et al. 1995. J. Immunol. 154, 4741. Bourinbaiar, A.S. and Nagorny, R. 1994. Cell Immunol. 155, 230. Biro, A., et al. 1992. Eur. J. Immunol. 22, 2547. Bruno, S., et al. 1992. Leukemia 6, 1113. Lee, S.F. 1992. Infect. Immun. 60, 4032. Schmidt, H.H., et al. 1992. Mol. Pharmacol. 41, 615.

参考信息概述

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

引用

标题

Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	18-September-2008 JSW
Synonyms	TLCK
Description	Inhibits trypsin-like serine proteases. Inactivates trypsin irreversibly without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC₅₀ = 80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes. Suggesting working concentration is 10-100 µM.
Form	Off-white solid
CAS number	4238-41-9
RTECS	XT5160000
Chemical formula	C₁₄H₂₁ClN₂O₃S . HCl
Structure formula
Purity	≥95% by elemental analysis
Solubility	Aqueous solutions pH <6.0 (1 mg/ml)
Storage	+2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Unstable in solution; reconstitute just prior to use.
Toxicity	Irritant
References	Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721. Kim, H., et al. 1995. J. Immunol. 154, 4741. Bourinbaiar, A.S. and Nagorny, R. 1994. Cell Immunol. 155, 230. Biro, A., et al. 1992. Eur. J. Immunol. 22, 2547. Bruno, S., et al. 1992. Leukemia 6, 1113. Lee, S.F. 1992. Infect. Immun. 60, 4032. Schmidt, H.H., et al. 1992. Mol. Pharmacol. 41, 615.
Citation	Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors

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616382 Sigma-AldrichN^α-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem

Inhibits trypsin-like serine proteinases.

同义词: TLCK

Recommended Products

概述

重要规格表

价格及供货情况

Documentation

N^α-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem MSDS

N^α-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem 分析证书

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小册子

引用

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Inhibits trypsin-like serine proteinases.

同义词: TLCK

Recommended Products

重要规格表

价格及供货情况

Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem MSDS

Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem 分析证书

参考

小册子

引用

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最近查看的内容

N^α-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem MSDS

N^α-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem 分析证书