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399275 Nω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem

概述

重要规格表

CAS #Empirical Formula
189302-40-7C₅H₁₂N₄O₃ · 2CH₃CO₂H

价格及供货情况

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399275-1MGCN
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      塑胶安瓿;塑胶针药瓶 1 mg
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      399275-5MGCN
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          塑胶安瓿;塑胶针药瓶 5 mg
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          Description
          OverviewA potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.
          Catalogue Number399275
          Brand Family Calbiochem®
          Synonymsnor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H
          References
          ReferencesGobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
          Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
          Moali, C., et al. 2000. Biochemistry 39, 8208.
          Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
          Moali, C., et al. 1998. Biochemistry 37, 10453.
          Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.
          Product Information
          CAS number189302-40-7
          FormOff-white solid
          Hill FormulaC₅H₁₂N₄O₃ · 2CH₃CO₂H
          Chemical formulaC₅H₁₂N₄O₃ · 2CH₃CO₂H
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationNω-Hydroxy-nor-L-arginine, Diacetate Salt, CAS 189302-40-7, is a potent, selective, competitive, and high affinity inhibitor of arginase (IC50 = 2 µM for rat liver and 50 µM for mouse macrophages).
          Biological Information
          Primary Targetarginase from rat liver
          Primary Target IC<sub>50</sub>2 µM
          Secondary targetmouse macrophages (IC₅₀ = 50 µM)
          Purity≥97% by TLC
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Global Trade Item Number
          产品目录编号 GTIN
          399275-1MGCN 04055977212563
          399275-5MGCN 07790788049881