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399275 Sigma-AldrichN^ω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem

Nω-Hydroxy-nor-L-arginine, Diacetate Salt, CAS 189302-40-7, is a potent, selective, competitive, and high affinity inhibitor of arginase (IC50 = 2 µM for rat liver and 50 µM for mouse macrophages).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: nor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H

Primary Target: arginase from rat liver

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
189302-40-7	C₅H₁₂N₄O₃ · 2CH₃CO₂H

价格及供货情况

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Description
Overview	A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC₅₀ = 2 µM) and mouse macrophages (IC₅₀ = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.
Catalogue Number	399275
Brand Family	Calbiochem®
Synonyms	nor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H

References
References	Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653. Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793. Moali, C., et al. 2000. Biochemistry 39, 8208. Tenu, J.P. et al. 1999. Nitric Oxide 3, 427. Moali, C., et al. 1998. Biochemistry 37, 10453. Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.

Product Information
CAS number	189302-40-7
Form	Off-white solid
Hill Formula	C₅H₁₂N₄O₃ · 2CH₃CO₂H
Chemical formula	C₅H₁₂N₄O₃ · 2CH₃CO₂H
Hygroscopic	Hygroscopic
Structure formula Image
Quality Level	MQ100

Applications
Application	Nω-Hydroxy-nor-L-arginine, Diacetate Salt, CAS 189302-40-7, is a potent, selective, competitive, and high affinity inhibitor of arginase (IC50 = 2 µM for rat liver and 50 µM for mouse macrophages).

Biological Information
Primary Target	arginase from rat liver
Primary Target IC<sub>50</sub>	2 µM
Secondary target	mouse macrophages (IC₅₀ = 50 µM)
Purity	≥97% by TLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
399275-1MGCN	04055977212563
399275-5MGCN	07790788049881

Documentation

N^ω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

N^ω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem 分析证书

标题	批号
399275	输入批号

参考

参考信息概述
Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653. Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793. Moali, C., et al. 2000. Biochemistry 39, 8208. Tenu, J.P. et al. 1999. Nitric Oxide 3, 427. Moali, C., et al. 1998. Biochemistry 37, 10453. Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.

小册子

标题
Pathways and Biomarkers of Oxidative Stress

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	16-October-2007 JSW
Synonyms	nor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H
Description	A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC₅₀ = 2 µM) and mouse macrophages (IC₅₀ = 50 µM). Specifically interacts with the manganese-cluster of the enzyme active site. Does not act as a substrate or as an inhibitor of NOS. Hence, it may serve as a useful tool to study the interplays between arginase and NOS.
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	189302-40-7
Chemical formula	C₅H₁₂N₄O₃ · 2CH₃CO₂H
Structure formula
Purity	≥97% by TLC
Solubility	H₂O (50 mg/ml)
Storage	-20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653. Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793. Moali, C., et al. 2000. Biochemistry 39, 8208. Tenu, J.P. et al. 1999. Nitric Oxide 3, 427. Moali, C., et al. 1998. Biochemistry 37, 10453. Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Nitric Oxide and Oxidative Stress > Arginase Inhibitors

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399275 Sigma-AldrichN^ω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem

Nω-Hydroxy-nor-L-arginine, Diacetate Salt, CAS 189302-40-7, is a potent, selective, competitive, and high affinity inhibitor of arginase (IC50 = 2 µM for rat liver and 50 µM for mouse macrophages).

同义词: nor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H

Recommended Products

概述

重要规格表

价格及供货情况

Documentation

N^ω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem MSDS

N^ω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem 分析证书

参考

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Nω-Hydroxy-nor-L-arginine, Diacetate Salt, CAS 189302-40-7, is a potent, selective, competitive, and high affinity inhibitor of arginase (IC50 = 2 µM for rat liver and 50 µM for mouse macrophages).

同义词: nor-NOHA, 2CH₃CO₂H, L-2-Amino-(4-(2ʹ-hydroxyguanidino)butyric Acid, 2CH₃CO₂H

Recommended Products

重要规格表

价格及供货情况

Nω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem MSDS

Nω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem 分析证书

参考

小册子

种类

最近查看的内容

N^ω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem MSDS

N^ω-Hydroxy-nor-L-arginine, Diacetate Salt - CAS 189302-40-7 - Calbiochem 分析证书