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475981 Sigma-AldrichMyosin Light Chain Kinase Inhibitor Peptide 18 - Calbiochem

The Myosin Light Chain Kinase Inhibitor Peptide 18 controls the biological activity of Myosin Light Chain Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: MLCK Inhibitor Peptide 18, H-RKKYKYRRK-NH₂, MLCK Inhibitor IV

Primary Target: Mlck

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概述

Replacement Information

重要规格表

Empirical Formula
C₆₀H₁₀₅N₂₃O₁₁

价格及供货情况

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Description
Overview	A highly basic, cell-permeable, nonapeptide that acts as a selective Myosin Light Chain Kinase (MLCK) inhibitor (IC₅₀ = 50 nM). The inhibition is competitive with respect to the peptide substrate (K_i = 52 nM) and displays a mixed mode of inhibition with respect to ATP. Does not interfere with kinase activation by calmodulin (CaM), nor does it inhibit the activities of CaMKII and PKA.
Catalogue Number	475981
Brand Family	Calbiochem®
Synonyms	MLCK Inhibitor Peptide 18, H-RKKYKYRRK-NH₂, MLCK Inhibitor IV

References
References	Zolotarevsky, Y., et al. 2002. Gastroenterology 123, 163. Lukas, T.J., et al. 1999. J. Med. Chem. 42, 910.

Product Information
ATP Competitive	N
Form	White lyophilized solid
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₆₀H₁₀₅N₂₃O₁₁
Chemical formula	C₆₀H₁₀₅N₂₃O₁₁
Hygroscopic	Hygroscopic
Reversible	N
Quality Level	MQ100

Applications

Biological Information
Primary Target	Mlck
Primary Target IC<sub>50</sub>	50 nM against MLCK
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH₂

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
475981-5MGCN	04055977184365

Documentation

Myosin Light Chain Kinase Inhibitor Peptide 18 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Myosin Light Chain Kinase Inhibitor Peptide 18 - Calbiochem 分析证书

标题	批号
475981	输入批号

参考

参考信息概述
Zolotarevsky, Y., et al. 2002. Gastroenterology 123, 163. Lukas, T.J., et al. 1999. J. Med. Chem. 42, 910.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-December-2008 JSW
Synonyms	MLCK Inhibitor Peptide 18, H-RKKYKYRRK-NH₂, MLCK Inhibitor IV
Description	A highly basic, cell-permable, nonapeptide that acts as a selective myosin light chain kinase (MLCK) inhibitor (IC₅₀ = 50 nM). Does not block calmodulin (CaM) or inhibit the kinase activities of Ca²⁺/calmodulin kinase II (CaMKII) or protein kinase A (PKA). Inhibition is competitive with respect to substrate (K_i = 52 nM). Displays mixed mode inhibition with respect to ATP.
Form	White lyophilized solid
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₆₀H₁₀₅N₂₃O₁₁
Peptide Sequence	H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH₂
Purity	≥97% by HPLC
Solubility	DMSO (5 mg/ml) or H₂O (1 mg/ml)
Storage	-20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Zolotarevsky, Y., et al. 2002. Gastroenterology 123, 163. Lukas, T.J., et al. 1999. J. Med. Chem. 42, 910.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors

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