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A constituent and psychoactive ingredient of the mushroom Amanita muscariathat acts as a potent agonist of GABAA receptors (EC50 = 28 µM and 33 µM in neonatal and adult rats, respectively), with preferential efficacy and selectivity to high-affinity receptor subtypes. Shown to be permeate the blood-brain barrier. Impairs associate and memory functions.
Catalogue Number
506044
Brand Family
Calbiochem®
Synonyms
GABAA Receptor Agonist, Muscimol
References
References
Chandra, D., et al. 2010. Neuropsychopharmacology.35, 999. Fischer, H., et al. 2005. J. Physiol.564, 465. Ramirez, D.R., et al. 2005. Neurobiol. Learning and Memory.84, 184.
If swallowed, seek medical advice immediately and show this container or label.
Product Usage Statements
Storage and Shipping Information
Ship Code
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Chandra, D., et al. 2010. Neuropsychopharmacology.35, 999. Fischer, H., et al. 2005. J. Physiol.564, 465. Ramirez, D.R., et al. 2005. Neurobiol. Learning and Memory.84, 184.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
12-September-2013 JSW
Synonyms
GABAA Receptor Agonist, Muscimol
Description
A constituent and psychoactive ingredient of the mushroom Amanita muscariathat acts as a potent agonist of GABAA receptors (EC50 = 28 µM and 33 µM in neonatal and adult rats, respectively), with preferential efficacy and selectivity to high-affinity receptor subtypes. Shown to be permeate the blood-brain barrier. Impairs associate and memory functions.
Form
White solid
CAS number
2763-96-4
Chemical formula
C₄H₆N₂O₂
Structure formula
Purity
≥99% by HPLC
Solubility
H₂O (100 mM)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Toxic
References
Chandra, D., et al. 2010. Neuropsychopharmacology.35, 999. Fischer, H., et al. 2005. J. Physiol.564, 465. Ramirez, D.R., et al. 2005. Neurobiol. Learning and Memory.84, 184.
