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475951
Sigma-AldrichMreB Perturbing Compound A22 - CAS 22816-60-0 - Calbiochem
A cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization.
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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. Reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with MreB's nucleotide binding pocket and is useful for the temporal analysis of MreB function.
Catalogue Number
475951
Brand Family
Calbiochem®
Synonyms
S-(3,4-Dichlorobenzyl)isothiourea, HCl
References
References
Gitai, Z., et al. 2005. Cell120, 329. Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol.3, 167. Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem.66, 2658.
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity
Standard Handling
Storage
+2°C to +8°C
Protect from Light
Protect from light
Hygroscopic
Hygroscopic
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution in DMSO, aliquot and freeze (-20°C. DMSO stock solutions are stable for up to 1 month at -20°C. Reconstitute in H₂O just prior to use; aqueous stock solutions are stable for up to 12 hr. Stable for up to 2 days in acidic medium.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
475951-25MGCN
07790788050580
Documentation
MreB Perturbing Compound A22 - CAS 22816-60-0 - Calbiochem MSDS
MreB Perturbing Compound A22 - CAS 22816-60-0 - Calbiochem 分析证书
标题
批号
475951
参考
参考信息概述
Gitai, Z., et al. 2005. Cell120, 329. Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol.3, 167. Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem.66, 2658.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
11-August-2008 RFH
Synonyms
S-(3,4-Dichlorobenzyl)isothiourea, HCl
Description
A cell-permeable isothiourea compound that specifically, rapidly, and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. Reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with the nucleotide binding pocket of MreB and is useful for the temporal analysis of MreB function.
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
22816-60-0
Chemical formula
C₈H₈Cl₂N₂S • HCl
Structure formula
Purity
≥95% by HPLC
Solubility
DMSO (200 mg/ml) or H₂O (2 mg/ml)
Storage
Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution in DMSO, aliquot and freeze (-20°C. DMSO stock solutions are stable for up to 1 month at -20°C. Reconstitute in H₂O just prior to use; aqueous stock solutions are stable for up to 12 hr. Stable for up to 2 days in acidic medium.
Toxicity
Standard Handling
References
Gitai, Z., et al. 2005. Cell120, 329. Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol.3, 167. Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem.66, 2658.