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475838 Sigma-AldrichMifepristone - CAS 84371-65-3 - Calbiochem

A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors.

Mifepristone - CAS 84371-65-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: (11β,17β)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one, RU-486

Primary Target: Progesterone and glucocorticoid receptors

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
84371-65-3	C₂₉H₃₅NO₂

价格及供货情况

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Description
Overview	A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Inhibits P-glycoprotein (P-gp) function and down-modulates P-gp mediated drug resistance. Displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Regulates the expression of Fas and FasL in mouse endometrium and TRAIL in prostate cancer cells. As an antioxidant, it offers neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Aβ-, H₂O₂-, and glutamate-induced injury to mouse hippocampal HT22 cells.
Catalogue Number	475838
Brand Family	Calbiochem®
Synonyms	(11β,17β)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one, RU-486

References
References	McCullers, D.L., et al. 2002. Neuroscience 109, 219. Sidell, N., et al. 2002. Ann. N. Y. Acad. Sci. 955, 159. Gao, F., et al. 2001. Acta Pharmacol. Sin. 22, 524. Hyder, S.M., et al. 2001. Int. J. Cancer 92, 469. Lam, F.C., et al. 2001. J. Neurochem. 76, 1121. Sridhar, S., et al. 2001. Cancer Res. 61, 7179. Behl, C., et al. 1997. Eur. J. Neurosci. 9, 912. Greb, R.R., et al. 1997. Hum. Reprod. 12, 1280. Gruol, D.J., et al. 1994. Cancer Res. 54, 3088.

References

McCullers, D.L., et al. 2002. Neuroscience 109, 219.
Sidell, N., et al. 2002. Ann. N. Y. Acad. Sci. 955, 159.
Gao, F., et al. 2001. Acta Pharmacol. Sin. 22, 524.
Hyder, S.M., et al. 2001. Int. J. Cancer 92, 469.
Lam, F.C., et al. 2001. J. Neurochem. 76, 1121.
Sridhar, S., et al. 2001. Cancer Res. 61, 7179.
Behl, C., et al. 1997. Eur. J. Neurosci. 9, 912.
Greb, R.R., et al. 1997. Hum. Reprod. 12, 1280.
Gruol, D.J., et al. 1994. Cancer Res. 54, 3088.

Product Information
CAS number	84371-65-3
ATP Competitive	N
Form	Yellow solid
Hill Formula	C₂₉H₃₅NO₂
Chemical formula	C₂₉H₃₅NO₂
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Progesterone and glucocorticoid receptors
Purity	≥99% by titration

Physicochemical Information
Cell permeable	Y
Contaminants	Steroid substances: ≤0.1%

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	KG2955000

Safety Information
R Phrase	R: 60-61 May impair fertility. May cause harm to the unborn child.
S Phrase	S: 22-36/37/39-45 Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
475838-50MGCN	04055977184976

Documentation

Mifepristone - CAS 84371-65-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Mifepristone - CAS 84371-65-3 - Calbiochem 分析证书

标题	批号
475838	输入批号

参考

参考信息概述
McCullers, D.L., et al. 2002. Neuroscience 109, 219. Sidell, N., et al. 2002. Ann. N. Y. Acad. Sci. 955, 159. Gao, F., et al. 2001. Acta Pharmacol. Sin. 22, 524. Hyder, S.M., et al. 2001. Int. J. Cancer 92, 469. Lam, F.C., et al. 2001. J. Neurochem. 76, 1121. Sridhar, S., et al. 2001. Cancer Res. 61, 7179. Behl, C., et al. 1997. Eur. J. Neurosci. 9, 912. Greb, R.R., et al. 1997. Hum. Reprod. 12, 1280. Gruol, D.J., et al. 1994. Cancer Res. 54, 3088.

参考信息概述

小册子

标题
Alzheimer's Disease Brochure & Technical Guide

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-April-2009 RFH
Synonyms	(11β,17β)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one, RU-486
Description	A cell-permeable, synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Reported to inhibit P-glycoprotein (P-gp) function and down-modulate P-gp mediated drug resistance. Also displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Shown to regulate the expression of Fas and FasL in mouse endometrium and of TRAIL in prostate cancer cells. As an antioxidant, it is reported to offer neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Aβ-, H₂O₂-, and glutamate-induced injury to mouse hippocampal HT22 cells.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	84371-65-3
RTECS	KG2955000
Chemical formula	C₂₉H₃₅NO₂
Structure formula
Purity	≥99% by titration
Contaminants	Steroid substances: ≤0.1%
Solubility	Ethanol (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
Merck USA index	14, 6186
References	McCullers, D.L., et al. 2002. Neuroscience 109, 219. Sidell, N., et al. 2002. Ann. N. Y. Acad. Sci. 955, 159. Gao, F., et al. 2001. Acta Pharmacol. Sin. 22, 524. Hyder, S.M., et al. 2001. Int. J. Cancer 92, 469. Lam, F.C., et al. 2001. J. Neurochem. 76, 1121. Sridhar, S., et al. 2001. Cancer Res. 61, 7179. Behl, C., et al. 1997. Eur. J. Neurosci. 9, 912. Greb, R.R., et al. 1997. Hum. Reprod. 12, 1280. Gruol, D.J., et al. 1994. Cancer Res. 54, 3088.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Angiogenesis Inhibitors > Angiogenesis Inhibitors

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