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An antagonist of the 5-HT2B (pki = 8.0-9.4) and 5-HT2C (pki = 8.6-9.1) receptor. At the 5-HT1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC50 = 18 µM. Originally developed in the 1960′s as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT2 receptor antagonist in both in vivo and in vitro experiments.
Wear suitable protective clothing, gloves and eye/face protection. If swallowed, seek medical advice immediately and show this container or label.
Product Usage Statements
Storage and Shipping Information
Ship Code
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
5.06419.0001
04055977242737
Documentation
Methysergide Maleate - CAS 129-49-7 - Calbiochem MSDS
Matsuta, Y. et al. 2013. Exp. Neurol.247, 250. IUHPAR Database 2013. Shad, K.F., Saeed, S.A. 2007. Exp. Brain Res.183, 411. Knight, A.R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114. Saxena, P.R and Lawang, A. 1985. Arch. Int. Pharmacodyn. Ther.277, 235. Colpaert, F. C. et al. 1979. Eur. J. Pharmacol.58, 505.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
An antagonist of the 5-HT2B (pki = 8.0-9.4) and 5-HT2C (pki = 8.6-9.1) receptor. At the 5-HT1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC50 = 18 µM. Originally developed in the 1960′s as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT2 receptor antagonist in both in vivo and in vitro experiments.
Form
Off-white solid
CAS number
129-49-7
Chemical formula
C₂₁H₂₇N₃O₂·C₄H₄O₄
Structure formula
Purity
≥99% by HPLC
Solubility
H₂O (10 mM)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Toxic
References
Matsuta, Y. et al. 2013. Exp. Neurol.247, 250. IUHPAR Database 2013. Shad, K.F., Saeed, S.A. 2007. Exp. Brain Res.183, 411. Knight, A.R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114. Saxena, P.R and Lawang, A. 1985. Arch. Int. Pharmacodyn. Ther.277, 235. Colpaert, F. C. et al. 1979. Eur. J. Pharmacol.58, 505.
