Millipore Sigma Vibrant Logo

445800 Merbarone - CAS 97534-21-9 - Calbiochem

概述

Replacement Information

重要规格表

CAS #Empirical Formula
97534-21-9C₁₁H₉N₃O₃S

价格及供货情况

产品目录编号 库存情况包装 数量 / 包装 价格 数量
445800-25MGCN
正在查询供货情况......
目前缺货
目前缺货
有货 
停产
少量现货
供货情况有待确认
    其余:另行通知
      其余:另行通知
      另行通知
      联系客户服务
      Contact Customer Service

      塑胶安瓿;塑胶针药瓶 25 mg
      正在检索价格......
      无法检索价格。
      最小订购数量为倍数
      Maximum Quantity is
      以订单确认为准 更多信息
      您节约了 ()。
       
      Request Pricing
      Description
      OverviewA cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 µM for purified mammalian topo II versus IC50 = ~ 200 µM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.
      Catalogue Number445800
      Brand Family Calbiochem®
      Synonyms5-(N-Phenylcarboxamido)-2-thiobarbituric Acid, NSC-336628
      References
      ReferencesKhelifa, T., and Beck, W.T. 1999. Mol. Pharmacol. 55, 548.
      Drake, F.H., et al. 1989. Cancer Res. 49, 2578.
      Brewer, A.D., et al. 1985. Biochem. Pharmacol. 34, 2047.
      Product Information
      CAS number97534-21-9
      ATP CompetitiveN
      FormFaint pink solid
      Hill FormulaC₁₁H₉N₃O₃S
      Chemical formulaC₁₁H₉N₃O₃S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCatalytic activity of topoisomerase II
      Primary Target IC<sub>50</sub>20 µM for purified topoisomerase II (topo II)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUV7714625
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      445800-25MGCN 04055977204568

      Documentation

      Merbarone - CAS 97534-21-9 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      Merbarone - CAS 97534-21-9 - Calbiochem 分析证书

      标题批号
      445800

      参考

      参考信息概述
      Khelifa, T., and Beck, W.T. 1999. Mol. Pharmacol. 55, 548.
      Drake, F.H., et al. 1989. Cancer Res. 49, 2578.
      Brewer, A.D., et al. 1985. Biochem. Pharmacol. 34, 2047.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-August-2008 RFH
      Synonyms5-(N-Phenylcarboxamido)-2-thiobarbituric Acid, NSC-336628
      DescriptionA cell-permeable, anticancer drug that inhibits the catalytic activity of DNA topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 µM for purified mammalian topoisomerase II versus IC50 ~200 µM for topoisomerase I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.
      FormFaint pink solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number97534-21-9
      RTECSUV7714625
      Chemical formulaC₁₁H₉N₃O₃S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Toxicity Standard Handling
      ReferencesKhelifa, T., and Beck, W.T. 1999. Mol. Pharmacol. 55, 548.
      Drake, F.H., et al. 1989. Cancer Res. 49, 2578.
      Brewer, A.D., et al. 1985. Biochem. Pharmacol. 34, 2047.