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444605 Melittin - CAS 37231-28-0 - Calbiochem

A 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner.

Melittin - CAS 37231-28-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: PKC
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444605
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
37231-28-0C₁₃₁H₂₂₉N₃₉O₃₁

价格及供货情况

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444605-250UGCN
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      		 玻璃瓶 250 μg
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      Description
      OverviewA 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner. A stimulator of Giα and G11α activity that is reported to inhibit adenylate cyclase activity in synaptic membranes. Activates phospholipase A2 and inhibits protein kinase C (IC50 = 5-7 µM) by binding to the catalytic domain in a Mg2+-ATP sensitive manner. Has also been used for affinity purification of several Ca2+-binding proteins.
      Catalogue Number444605
      Brand Family Calbiochem®
      References
      ReferencesFukushima, N., et al. 1998. Peptides 19, 811.
      Gravitt, K.R. 1994. Biochem. Pharmacol. 47, 425.
      Baudier, J., et al. 1987. Biochemistry 26, 2886.
      Kincaid, R.L., and Coulson, C.C. 1985. Biochem. Biophys. Res. Commun. 133, 256.
      Product Information
      CAS number37231-28-0
      ATP CompetitiveN
      FormLyophilized
      Hill FormulaC₁₃₁H₂₂₉N₃₉O₃₁
      Chemical formulaC₁₃₁H₂₂₉N₃₉O₃₁
      ReversibleN
      Sold on the basis of peptide contentY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>5-7 µM 5-7 µM for activating phospholipase A2 and inhibits protein kinase C
      Purity>97% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide ContentY
      Peptide SequenceH-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSOS3960000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      444605-250UGCN 04055977186130

      Documentation

      Melittin - CAS 37231-28-0 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      Melittin - CAS 37231-28-0 - Calbiochem 分析证书

      标题批号
      444605

      参考

      参考信息概述
      Fukushima, N., et al. 1998. Peptides 19, 811.
      Gravitt, K.R. 1994. Biochem. Pharmacol. 47, 425.
      Baudier, J., et al. 1987. Biochemistry 26, 2886.
      Kincaid, R.L., and Coulson, C.C. 1985. Biochem. Biophys. Res. Commun. 133, 256.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-May-2008 RFH
      DescriptionA 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner, activates phospholipase A2, and inhibits protein kinase C (IC50 = 5-7 µM) by binding to the catalytic domain in a Mg2+-ATP sensitive manner. A stimulator of Giα and G11α activity that is reported to inhibit adenylate cyclase activity in synaptic membranes. Has also been used for affinity purification of several Ca2+-binding proteins. Activates Giα-1 and G11α activities and inhibits Gs activity.
      FormLyophilized
      CAS number37231-28-0
      RTECSOS3960000
      Chemical formulaC₁₃₁H₂₂₉N₃₉O₃₁
      Peptide SequenceH-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH₂
      Purity>97% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 5824
      ReferencesFukushima, N., et al. 1998. Peptides 19, 811.
      Gravitt, K.R. 1994. Biochem. Pharmacol. 47, 425.
      Baudier, J., et al. 1987. Biochemistry 26, 2886.
      Kincaid, R.L., and Coulson, C.C. 1985. Biochem. Biophys. Res. Commun. 133, 256.