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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

444130 Sigma-AldrichMcl-1 Inhibitor, MIM1 - Calbiochem

Mcl-1 Inhibitor, MIM1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: Mcl-1 Inhibitor Molecule 1, 4-((E)-((Z)-2-(cyclohexylimino)-4-methylthiazol-3(2H)-ylimino)methyl)benzene-1,2,3-triol

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概述

Replacement Information

价格及供货情况

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Description
Overview	A cell-permeable thiazolyliminopyrogallol that selectively neutralizes Mcl-1, but not Bcl-X_L, antiapoptotic activity by directly targeting Mcl-1 BH3-binding site, effectively competing against Bid BH3 sequence for Mcl-1 binding (IC₅₀ = 4.8 µM). Shown to induce caspase 3/7 activation and cell death in Mcl-1-, but not Bcl-X_L-, dependent B-ALL cultures (6% vs. 82% survival, respectively; 10 µM). In comparison, ABT-737 (Cat. No. 197333) affects only Bcl-X_L-, but not Mcl-1-, dependent B-ALL cells. Neither MIM1 nor ABT-737 significantly affects the survival of wild-type or Bax^-/-Bak^-/- MEF.
Catalogue Number	444130
Brand Family	Calbiochem®
Synonyms	Mcl-1 Inhibitor Molecule 1, 4-((E)-((Z)-2-(cyclohexylimino)-4-methylthiazol-3(2H)-ylimino)methyl)benzene-1,2,3-triol

References
References	Cohen, N.A., et al. 2012. Chem. Biol. 19, 1175.

Product Information
Form	Yellow powder
Hill Formula	C₁₇H₂₁N₃O₃S
Chemical formula	C₁₇H₂₁N₃O₃S
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Mcl-1
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
444130-25MGCN	04055977205428

Documentation

Mcl-1 Inhibitor, MIM1 - Calbiochem 分析证书

标题	批号
444130	输入批号

参考

参考信息概述
Cohen, N.A., et al. 2012. Chem. Biol. 19, 1175.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	04-July-2013 JSW
Synonyms	Mcl-1 Inhibitor Molecule 1, 4-((E)-((Z)-2-(cyclohexylimino)-4-methylthiazol-3(2H)-ylimino)methyl)benzene-1,2,3-triol
Description	A cell-permeable thiazolyliminopyrogallol that selectively neutralizes Mcl-1, but not Bcl-X_L, antiapoptotic activity, by directly targeting Mcl-1 BH3-binding site, effectively competing against Bid BH3 sequence for Mcl-1 binding (IC₅₀ = 4.8 µM) without affecting Bcl-X_L interaction with Bad or Bid BH3 sequence (IC₅₀ >50 µM). Shown to induce caspase 3/7 activation and cell death in Mcl-1-, but not Bcl-X_L-, dependent B-ALL cultures (6% vs. 82% survival, respectively, [MIM1] = 10 µM). In comparison, ABT-737 (Cat. No. 197333) affects only Bcl-X_L-, but not Mcl-1-, dependent B-ALL cultures (0% vs. 98% survival, respectively, [ABT-737] = 10 µM). Neither MIM1 nor ABT-737 significantly affects the survival of wild-type (81% and 79% survival in the presence of 10 µM respective inhibitor) or Bax^-/-Bak^-/- MEF (93% and 84% survival in the presence of 10 µM respective inhibitor).
Form	Yellow powder
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₁₇H₂₁N₃O₃S
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Cohen, N.A., et al. 2012. Chem. Biol. 19, 1175.

种类

Life Science Research > Inhibitors and Biochemicals

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