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444256 Sigma-AldrichMMP Substrate III, Fluorogenic - Calbiochem

A specific fluorogenic resonance energy transfer (FRET) peptide substrate with an MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencher combination.

MMP Substrate III, Fluorogenic - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: DABCYL-GABA-PQGL-E(EDANS)-AK-NH₂, TNO211

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概述

Replacement Information

价格及供货情况

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Description
Overview	A specific fluorogenic resonance energy transfer (FRET) peptide substrate with an MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencher combination. Useful for the detection of MMP activity [k_cat/K_m = 619,000 M^-1s^-1 for MMP-2, 206,000 M^-1s^-1 for MMP-9, 40,000 M^-1s^-1 for MMP-3, and 21,000 M^-1s^-1 for MMP-1; at 37°C, pH 7.6 ]. Exhibits a high degree of sensitivity that is not affected by optical disturbances in biological media. Also useful for MMP activity measurements in synovial fluid and culture medium.
Catalogue Number	444256
Brand Family	Calbiochem®
Synonyms	DABCYL-GABA-PQGL-E(EDANS)-AK-NH₂, TNO211

References
References	Beekman, B., et al. 1996. FEBS Lett 390, 221.

Product Information
ATP Competitive	N
Form	Red lyophilized solid
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₆₃H₈₈N₁₆O₁₄S
Chemical formula	C₆₃H₈₈N₁₆O₁₄S
Reversible	N
Quality Level	MQ100

Applications

Biological Information
Primary Target	Detection of MMP activity
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	N
Emission max.
Excitation max.
Peptide Sequence	DABCYL-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH₂

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
444256-500UGCN	04055977186543

Documentation

MMP Substrate III, Fluorogenic - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

MMP Substrate III, Fluorogenic - Calbiochem 分析证书

标题	批号
444256	输入批号

参考

参考信息概述
Beekman, B., et al. 1996. FEBS Lett 390, 221.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-August-2008 RFH
Synonyms	DABCYL-GABA-PQGL-E(EDANS)-AK-NH₂, TNO211
Description	A fluorescence energy transfer (FRET) peptide substrate with MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencher combination. Useful for the detection of MMP activity (k_cat/K_m = 619,000 M^-1s^-1 for MMP-2, 206,000 M^-1s^-1 for MMP-9, 40,000 M^-1s^-1 for MMP-3, 21,000 M^-1s^-1 for MMP-1; pH = 7.6 at 37°C). Exhibits a high degree of sensitivity, which is not affected by optical disturbances in biological media. Excitation max.: ~340 nm; emission max.: ~485 nm.
Form	Red lyophilized solid
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₆₃H₈₈N₁₆O₁₄S
Peptide Sequence	DABCYL-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH₂
Purity	≥97% by HPLC
Solubility	DMSO and Tris buffered saline (pH 7.6)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Beekman, B., et al. 1996. FEBS Lett 390, 221.

种类

Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Protease Substrates

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