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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

444290 Sigma-AldrichMMP Inhibitor V - CAS 223472-31-9 - Calbiochem

The MMP Inhibitor V, also referenced under CAS 223472-31-9, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: (2S,4S)-N-Hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide, ONO-4817

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
223472-31-9	C₂₂H₂₈N₂O₆

价格及供货情况

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Description
Overview	An orally active non-peptidyl hydroxamate compound that acts as an effective broad-spectrum inhibitor against MMP-2, -3, -8, -9, -12, -13 (K_i = 0.73, 42, 1.1, 2.1, 0.45, and 1.1 nM, respectively), but not MMP-1 (IC₅₀ = 1.6 µM), MMP-7 (K_i = 2.5 µM), or other serine proteases (no activity against chymotrypsin or plasmin at 100 µM). Widely used in studying MMP-mediated diseases development in vivo. Also reported to block P-LAP secretase activity (≥70% inhibition of P-LAP shedding at 10 µM) that is otherwise not inhibited by TIMP-1/2 in CHO cell cultures in vitro.
Catalogue Number	444290
Brand Family	Calbiochem®
Synonyms	(2S,4S)-N-Hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide, ONO-4817

References
References	Okamoto, Y., et al. 2007. Int. Heart J. 48, 369. Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314, 1008. Shiraga, M., et al. 2002. Cancer Res. 62, 5967. Mori, T., et al. 2001. Exp. Biol. Med. 226, 429. Yamada, A., et al. 2000. Inflamm. Res. 49, 144.

Product Information
CAS number	223472-31-9
Form	Off-white solid
Hill Formula	C₂₂H₂₈N₂O₆
Chemical formula	C₂₂H₂₈N₂O₆
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
444290-2MGCN	04055977186079

Documentation

MMP Inhibitor V - CAS 223472-31-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

MMP Inhibitor V - CAS 223472-31-9 - Calbiochem 分析证书

标题	批号
444290	输入批号

参考

参考信息概述
Okamoto, Y., et al. 2007. Int. Heart J. 48, 369. Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314, 1008. Shiraga, M., et al. 2002. Cancer Res. 62, 5967. Mori, T., et al. 2001. Exp. Biol. Med. 226, 429. Yamada, A., et al. 2000. Inflamm. Res. 49, 144.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	06-April-2009 RFH
Synonyms	(2S,4S)-N-Hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide, ONO-4817
Description	An orally active non-peptidyl hydroxamate compound that acts as an effective broad-spectrum inhibitor against MMP-2/3/8/9/12/13 (K_i = 0.73, 42, 1.1, 2.1, 0.45, and 1.1 nM, respectively), but not MMP-1 (IC₅₀ = 1.6 µM), MMP-7 (K_i = 2.5 µM), or other serine proteases (no activity against chymotrypsin or plasmin at 100 µM). Widely used in studying MMP-mediated diseases development in vivo. Also reported to block P-LAP secretase activity (≥70% inhibition of P-LAP shedding at 10 µM) that is otherwise not inhibited by TIMP-1/2 in CHO cell cultures in vitro.
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	223472-31-9
Chemical formula	C₂₂H₂₈N₂O₆
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (30 mg/ml) or Ethanol (15 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Okamoto, Y., et al. 2007. Int. Heart J. 48, 369. Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314, 1008. Shiraga, M., et al. 2002. Cancer Res. 62, 5967. Mori, T., et al. 2001. Exp. Biol. Med. 226, 429. Yamada, A., et al. 2000. Inflamm. Res. 49, 144.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Matrix Metalloproteinase (MMP) Inhibitors

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