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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

444284 Sigma-AldrichMMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem

The MMP-2/MMP-3 Inhibitor III, PD166793, also referenced under CAS 199850-67-4, controls the biological activity of MMP-2/MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: (S)-2-(4ʹ-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)

Primary Target: MMP-2, -3, and -13

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
199850-67-4	C₁₇H₁₈BrNO₄S

价格及供货情况

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Description
Overview	A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC₅₀ = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 µM), MMP-1, -7, -9, and -14 (IC₅₀ = 6.1, 7.2, 7.9, and 0.24 µM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.
Catalogue Number	444284
Brand Family	Calbiochem®
Synonyms	(S)-2-(4ʹ-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)

References
References	Paolocci, N., et al. 2006. J. Pharm. Exp. Ther. 317, 506. Zhou, Y.P., et al. 2005. Diabetes 54, 2612. Peterson, J.T., et al. 2001. Circulation 103, 2303. Spinale, F.G., et al. 1999. Circ. Res. 85, 364.

Product Information
CAS number	199850-67-4
ATP Competitive	N
Form	Off-white solid
Hill Formula	C₁₇H₁₈BrNO₄S
Chemical formula	C₁₇H₁₈BrNO₄S
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	MMP-2, -3, and -13
Primary Target IC<sub>50</sub>	47, 12, and 8 nM, against MMP-2, -3, and -13, respectively
Purity	≥98% by TLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
444284-5MGCN	04055977186017

Documentation

MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem 分析证书

标题	批号
444284	输入批号

参考

参考信息概述
Paolocci, N., et al. 2006. J. Pharm. Exp. Ther. 317, 506. Zhou, Y.P., et al. 2005. Diabetes 54, 2612. Peterson, J.T., et al. 2001. Circulation 103, 2303. Spinale, F.G., et al. 1999. Circ. Res. 85, 364.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-August-2008 RFH
Synonyms	(S)-2-(4ʹ-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)
Description	A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC₅₀ = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 µM), MMP-1, -7, -9, and -14 (IC₅₀ = 6.1, 7.2, 7.9, and 0.24 µM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.
Form	Off-white solid
CAS number	199850-67-4
Chemical formula	C₁₇H₁₈BrNO₄S
Structure formula
Purity	≥98% by TLC
Solubility	DMSO (40 mg/ml) or Ethanol (40 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Irritant
References	Paolocci, N., et al. 2006. J. Pharm. Exp. Ther. 317, 506. Zhou, Y.P., et al. 2005. Diabetes 54, 2612. Peterson, J.T., et al. 2001. Circulation 103, 2303. Spinale, F.G., et al. 1999. Circ. Res. 85, 364.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Matrix Metalloproteinase (MMP) Inhibitors

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