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475864 Sigma-AldrichMK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem

MK-2 Inhibitor III, CAS 1186648-22-5, is a cell-permeable, ATP-competitive inhibitor of MK-2/MAPKAP-K2 (IC50 = 8.5, 81 & 210 nM against MK-2, MK-5 & MK-3, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2-(2-Quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
1186648-22-5	C₂₁H₁₆N₄O • H₂O

价格及供货情况

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Description
Overview	A cell-permeable pyrrolopyridinyl compound that acts as an ATP-competitive inhibitor of MK-2/MAPKAP-K2 (IC₅₀ = 8.5, 81, and 210 nM against MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC₅₀ = 4.4 µM).
Catalogue Number	475864
Brand Family	Calbiochem®
Synonyms	2-(2-Quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one

References
References	Anderson, D.R., et al. 2007. J. Med. Chem. 50, 2647.

Product Information
CAS number	1186648-22-5
Form	Pale yellow solid
Hill Formula	C₂₁H₁₆N₄O • H₂O
Chemical formula	C₂₁H₁₆N₄O • H₂O
Structure formula Image
Quality Level	MQ100

Applications
Application	MK-2 Inhibitor III, CAS 1186648-22-5, is a cell-permeable, ATP-competitive inhibitor of MK-2/MAPKAP-K2 (IC50 = 8.5, 81 & 210 nM against MK-2, MK-5 & MK-3, respectively).

Biological Information
Purity	≥97% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
475864-5MGCN	04055977203400

Documentation

MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem 分析证书

标题	批号
475864	输入批号

参考

参考信息概述
Anderson, D.R., et al. 2007. J. Med. Chem. 50, 2647.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-April-2011 RFH
Synonyms	2-(2-Quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one
Description	A cell-permeable pyrrolopyridinyl compound that acts as a potent, selective, and ATP-biniding site-targeting MK-2/MAPKAP-K2 inhibitor (IC₅₀ = 8.5, 81, and 210 nM agaisnt MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC₅₀ = 4.4 µM).
Form	Pale yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	1186648-22-5
Chemical formula	C₂₁H₁₆N₄O • H₂O
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Anderson, D.R., et al. 2007. J. Med. Chem. 50, 2647.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors

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