444966 Sigma-AldrichMEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem
MEK1/2 Inhibitor III, CAS 391210-10-9, is a cell-permeable, non-competitive, highly potent MEK/MAPKK/MKK inhibitor that blocks cellular Erk1/2 phosphorylation (IC50 = 25 in serum starved HeLa cells).
More>> MEK1/2 Inhibitor III, CAS 391210-10-9, is a cell-permeable, non-competitive, highly potent MEK/MAPKK/MKK inhibitor that blocks cellular Erk1/2 phosphorylation (IC50 = 25 in serum starved HeLa cells). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: PD325901, PD0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD 0325901, MEK Inhibitor III
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概述
重要规格表
CAS # | Empirical Formula |
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391210-10-9 | C₁₆H₁₄F₃IN₂O₄ |
价格及供货情况
产品目录编号 | 库存情况 | 包装 | 数量 / 包装 | 价格 | 数量 | |
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444966-5MGCN |
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塑胶安瓿;塑胶针药瓶 | 5 mg |
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Description | |
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Overview | A cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumor in vivo. Also available in InSolution™ format (Cat. No. 444968). |
Catalogue Number | 444966 |
Brand Family | Calbiochem® |
Synonyms | PD325901, PD0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD 0325901, MEK Inhibitor III |
Product Information | |
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CAS number | 391210-10-9 |
Form | White to off-white solid |
Hill Formula | C₁₆H₁₄F₃IN₂O₄ |
Chemical formula | C₁₆H₁₄F₃IN₂O₄ |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Purity | ≥95% by HPLC |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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产品目录编号 | GTIN |
444966-5MGCN | 04055977204520 |