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504173 Sigma-AldrichMAT2A Inhibitor II, FIDAS-5 - CAS 1391934-98-7 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: Methionine S-Adenosyltransferase 2A Inhibitor II, FIDAS5, (E)-4-(2-Chloro-6-fluorostyryl)-N-methylaniline

Primary Target: MAT2A

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
1391934-98-7	C₁₅H₁₃ClFN

价格及供货情况

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Description
Overview	A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) analogue of FIDAS-3 (Cat. No. 681677) that competes against SAM for MAT2A binding and is >2-fold more potent than FIDAS-3 in inhibiting MAT2A-catalyzed SAM synthesis both in cell-free assays (IC₅₀ = 2.1 µM) and in LS174T colorectal cancer (CRC) cultures (3 µM). FIDAS-5 at 3 µM is shown to completely inhibit the proliferation of LS174T for up to 7 d in vitro and effectively suppress HT29 CRC tumor expansion in mice in vivo (20 mg/kg/day p.o.).
Catalogue Number	504173
Brand Family	Calbiochem®
Synonyms	Methionine S-Adenosyltransferase 2A Inhibitor II, FIDAS5, (E)-4-(2-Chloro-6-fluorostyryl)-N-methylaniline

References
References	Zhang, W., et al. 2013. ACS Chem. Biol. 8, 796.

Product Information
CAS number	1391934-98-7
Form	Yellow semi-solid
Hill Formula	C₁₅H₁₃ClFN
Chemical formula	C₁₅H₁₃ClFN
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	MAT2A
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.04173.0001	04055977263831

Documentation

MAT2A Inhibitor II, FIDAS-5 - CAS 1391934-98-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

MAT2A Inhibitor II, FIDAS-5 - CAS 1391934-98-7 - Calbiochem 分析证书

标题	批号
504173	输入批号

参考

参考信息概述
Zhang, W., et al. 2013. ACS Chem. Biol. 8, 796.

小册子

标题
New Products Flyer- Feb 2014 - Vol 1

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	18-June-2020 JSW
Synonyms	Methionine S-Adenosyltransferase 2A Inhibitor II, FIDAS5, (E)-4-(2-Chloro-6-fluorostyryl)-N-methylaniline
Description	A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) analogue of FIDAS-3 (Cat. No. 681677) that is >2-fold more potent than FIDAS-3 in inhibiting MAT2A-catalyzed SAM (S-adenosylmethionine) synthesis both in cell-free (IC₅₀ = 2.1 µM with FIDAS-5 vs. 4.9 µM with FIDAS-3; [L-Met] = [ATP] = 1 mM, [MAT2A] = 10 µg/mL; 20 min FIDAS preincubation prior to 30 min reaction) and cell-based (64% and 56% decrease of SAM and SAH level, respectively, in LS174T cells after 36 h treatment with either 3 µM FIDAS-5 or 10 µM FIDAS-3) assays. FIDAS-5 at 3 µM is shown to completely inhibit the proliferation of LS174T CRC (colorectal cancer) for up to 7 d in vitro and, when administered orally, effectively suppress HT29 CRC tumor expansion in mice in vivo (by 58% on d 18 post HT29 xenograft; 20 mg/kg/day starting d 4). Computer-aided in silico modeling predicts that FIDAS-3 & -5 target SAM-binding pocket at the interface of MAT2A dimer and in vitro binding studies reveals FIDAS-3 effectively competes against SAM for MAT2A binding.
Form	Yellow semi-solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	1391934-98-7
Chemical formula	C₁₅H₁₃ClFN
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (100 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Zhang, W., et al. 2013. ACS Chem. Biol. 8, 796.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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