数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

475741 Sigma-AldrichMAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem

The MAGL Inhibitor III, JZL184, also referenced under CAS 1101854-58-3, controls the biological activity of MAGL.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 4-Nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate, Monoacylglycerol Lipase Inhibitor III, JZL184

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
1101854-58-3	C₂₇H₂₄N₂O₉

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
475741-10MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	10 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A cell-permeable, blood-brain-barrier-permeant, and orally available carbamate compound that selectively inhibit MAGL (monoacylglycerol lipase) activity over FAAH (fatty acid amide hydrolase) and 35 other murine brain serine hydrolases, both in vitro (IC₅₀ = 6 - 8 nM against 2-AG hydrolysis by MAGL vs. 4 µM against anandamide/AEA hydrolysis by FAAH) and in mice in vivo (5-fold 2-AG enhancement and 75% MAGL activity inhibition in brain membrane from mice 4 hr after a single JZL184 dosage at 4 mg/kg via i.p.) in an irreversible, time- and dose-dependent manner. A great complement to the FAAH inhibitor URB597 (Cat. No. 341249) in differentiating the roles of CB1 and CB2 (type I and II cannabinoid receptors) in eCB- (endocannabinoid) mediated cellular signaling and in vivo physiological effects. Reported to be equally effective against human and murine MAGL, but inhibit rat MAGL with a ~10-fold lower potency.
Catalogue Number	475741
Brand Family	Calbiochem®
Synonyms	4-Nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate, Monoacylglycerol Lipase Inhibitor III, JZL184

References
References	Nomura, D.K., et al. 2010. Cell 140, 49. Long, J.Z., et al. Nature Chem. Biol. 16, 744. Long, J.Z., et al. 2009. Nature Chem. Biol. 5, 37. Pan, B., et al. 2009. J. Pharmacol. Exp. Ther. 331, 591.

Product Information
CAS number	1101854-58-3
Form	White to off-white solid
Hill Formula	C₂₇H₂₄N₂O₉
Chemical formula	C₂₇H₂₄N₂O₉
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥97% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
475741-10MGCN	04055977185577

Documentation

MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem 分析证书

标题	批号
475741	输入批号

参考

参考信息概述
Nomura, D.K., et al. 2010. Cell 140, 49. Long, J.Z., et al. Nature Chem. Biol. 16, 744. Long, J.Z., et al. 2009. Nature Chem. Biol. 5, 37. Pan, B., et al. 2009. J. Pharmacol. Exp. Ther. 331, 591.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	17-December-2018 JSW
Synonyms	4-Nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate, Monoacylglycerol Lipase Inhibitor III, JZL184
Description	A cell-permeable, blood-brain-barrier-permeant, and orally available carbamate compound that selectively inhibit MAGL (monoacylglycerol lipase) activity over FAAH (fatty acid amide hydrolase) and 35 other murine brain serine hydrolases, both in vitro (IC₅₀ = 6-8 nM against 2-AG hydrolysis by MAGL vs. 4 µM against anandamide/AEA hydrolysis by FAAH) and in mice in vivo (5-fold 2-AG enhancement and 75% MAGL activity inhibition in brain membrane from mice 4 hr after a single JZL184 dosage at 4 mg/kg via i.p.) in an irreversible, time- and dose-dependent manner. A great complement to the FAAH inhibitor URB597 (Cat. No. 341249) in differentiating the roles of CB1 and CB2 (type I and II cannabinoid receptors) in eCB- (endocannabinoid) mediated cellular signaling and in vivo physiological effects. Reported to be equally effective against human and murine MAGL, but inhibit rat MAGL with a ~10-fold lower potency.
Form	White to off-white solid
CAS number	1101854-58-3
Chemical formula	C₂₇H₂₄N₂O₉
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Nomura, D.K., et al. 2010. Cell 140, 49. Long, J.Z., et al. Nature Chem. Biol. 16, 744. Long, J.Z., et al. 2009. Nature Chem. Biol. 5, 37. Pan, B., et al. 2009. J. Pharmacol. Exp. Ther. 331, 591.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Monoacylglycerol Lipase Inhibitors

此产品已添加到您的购物车。