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119114 Sigma-AldrichLuciferase Inhibitor II - CAS 10205-56-8 - Calbiochem

The Luciferase Inhibitor II, also referenced under CAS 10205-56-8, controls the biological activity of Luciferase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 4-(1,3-Benzothiazol-2-yl)-N,N-dimethylaniline

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
10205-56-8	C₁₅H₁₄N₂S

价格及供货情况

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Description
Overview	A 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependent Photinus pyralis (lucPpy) and Photuris pennsylvanica (lucPpe) luciferase activity (IC₅₀ = 0.2 and 0.32 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency against lucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC₅₀ = 10 µM against Promega's Kinase-Glo^®; ineffective against Kinase-Glo^® Plus and Kinase-Glo^® Max; at a 3-fold formulation dilution and 6.77 µM ATP).
Catalogue Number	119114
Brand Family	Calbiochem®
Synonyms	4-(1,3-Benzothiazol-2-yl)-N,N-dimethylaniline

References
References	Auld, D.S., et al. 2009. J. Med. Chem. 52, 1450. Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.

Product Information
CAS number	10205-56-8
Declaration	Marketed by Promega Corp. under the registered trademarks.
Form	Pale green solid
Hill Formula	C₁₅H₁₄N₂S
Chemical formula	C₁₅H₁₄N₂S
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 22 Harmful if swallowed.
S Phrase	S: 22-26-36 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
119114-5MGCN	04055977223248

Documentation

Luciferase Inhibitor II - CAS 10205-56-8 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Luciferase Inhibitor II - CAS 10205-56-8 - Calbiochem 分析证书

标题	批号
119114	输入批号

参考

参考信息概述
Auld, D.S., et al. 2009. J. Med. Chem. 52, 1450. Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	04-April-2011 RFH
Synonyms	4-(1,3-Benzothiazol-2-yl)-N,N-dimethylaniline
Description	A 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependent Photinus pyralis (lucPpy) and Photuris pennsylvanica (lucPpe) luciferase activity (IC₅₀ = 0.2 and 0.32 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency against lucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC₅₀ = 10 µM against Promega's Kinase-Glo^®; ineffective against Kinase-Glo^® Plus and Kinase-Glo^® Max; at a 3-fold formulation dilution and 6.77 µM ATP).
Form	Pale green solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	10205-56-8
Chemical formula	C₁₅H₁₄N₂S
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (0.5 mg/ml) or Ethanol (3 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Harmful
References	Auld, D.S., et al. 2009. J. Med. Chem. 52, 1450. Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Luciferase Inhibitors

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