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438186 Sigma-AldrichLovastatin, Sodium Salt - Calbiochem

Carboxylate form of Lovastatin that is active in whole cells and cell-free assays.

Lovastatin, Sodium Salt - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: L-Type Calcium Channel Blocker IV

Primary Target: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase

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概述

Replacement Information

重要规格表

Empirical Formula
C₂₄H₃₇O₆ • Na

价格及供货情况

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Description
Overview	Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays.
Catalogue Number	438186
Brand Family	Calbiochem®
Synonyms	L-Type Calcium Channel Blocker IV

References
References	Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197. Carel, K., et al. 1996. J. Biol. Chem. 271, 30625. McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402. Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199. Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233. Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.

Product Information
ATP Competitive	N
Form	Off-white solid
Hill Formula	C₂₄H₃₇O₆ • Na
Chemical formula	C₂₄H₃₇O₆ • Na
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ200

Applications

Biological Information
Primary Target	3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions in high quality ethanol are stable for up to 1 month at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
438186-5MGCN	07790788050276

Documentation

Lovastatin, Sodium Salt - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Lovastatin, Sodium Salt - Calbiochem 分析证书

标题	批号
438186	输入批号

参考

参考信息概述
Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197. Carel, K., et al. 1996. J. Biol. Chem. 271, 30625. McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402. Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199. Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233. Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	06-August-2008 RFH
Synonyms	L-Type Calcium Channel Blocker IV
Description	Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21^ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21^ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G₁ phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF.
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₄H₃₇O₆ • Na
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (100 mg/ml) or Ethanol (50 mg/ml)
Storage	-20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions in high quality ethanol are stable for up to 1 month at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197. Carel, K., et al. 1996. J. Biol. Chem. 271, 30625. McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402. Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199. Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233. Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > HMG-CoA (3-Hydroxy-3-Methylglutaryl Coenzyme A) Reductase Inhibitors

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