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428150 Lavendustin A - CAS 125697-92-9 - Calbiochem

A cell-permeable, reversible, and substrate competitive inhibitor of EGF receptor tyrosine kinase and p60c-src with little effect on protein kinase A or protein kinase C.

Lavendustin A - CAS 125697-92-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 5-Amino-[(N-2,5-dihydroxybenzyl)-Nʹ-2-hydroxybenzyl]salicylic Acid, RG14355

Primary Target: EGF receptor tyrosine kinase
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428150
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
125697-92-9C₂₁H₁₉NO₆

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      Description
      OverviewA cell-permeable, reversible, and substrate competitive inhibitor of EGF receptor tyrosine kinase (IC50 = 11 nM) and p60c-src (IC50 = 500 nM) with little effect on protein kinase A or protein kinase C (IC50 > 200 µM). Also inhibits NMDA-stimulated cGMP production (IC50 = 30 nM). Exhibits anti-proliferative properties. Suppresses the angiogenic action of vascular endothelial growth factor (VEGF) in rats.
      Catalogue Number428150
      Brand Family Calbiochem®
      Synonyms5-Amino-[(N-2,5-dihydroxybenzyl)-Nʹ-2-hydroxybenzyl]salicylic Acid, RG14355
      References
      ReferencesHu, D.E., and Fan, T.-P. 1995. Br. J. Pharmacol. 114, 262.
      Rodriguez, J., et al. 1994. Neuropharmacology 33, 1267.
      Hsu, C.-Y., et al. 1991. J. Biol. Chem. 266, 21105.
      O’Dell, T.J., et al. 1991. Nature 353, 558; Onoda, T., et al. 1989. J. Nat. Prod. 52, 1252.
      Bishop, J.M. 1983. Annu. Rev. Biochem. 52, 307.
      Product Information
      CAS number125697-92-9
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₁H₁₉NO₆
      Chemical formulaC₂₁H₁₉NO₆
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEGF receptor tyrosine kinase
      Primary Target IC<sub>50</sub>11 nM and 500 nM against EGF receptor tyrosine kinase and p60c-src, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      428150-1MGCN 04055977210545

      Documentation

      Lavendustin A - CAS 125697-92-9 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      Lavendustin A - CAS 125697-92-9 - Calbiochem 分析证书

      标题批号
      428150

      参考

      参考信息概述
      Hu, D.E., and Fan, T.-P. 1995. Br. J. Pharmacol. 114, 262.
      Rodriguez, J., et al. 1994. Neuropharmacology 33, 1267.
      Hsu, C.-Y., et al. 1991. J. Biol. Chem. 266, 21105.
      O’Dell, T.J., et al. 1991. Nature 353, 558; Onoda, T., et al. 1989. J. Nat. Prod. 52, 1252.
      Bishop, J.M. 1983. Annu. Rev. Biochem. 52, 307.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      Synonyms5-Amino-[(N-2,5-dihydroxybenzyl)-Nʹ-2-hydroxybenzyl]salicylic Acid, RG14355
      DescriptionA cell-permeable, reversible, substrate competitive, and potent inhibitor of EGF receptor tyrosine kinase (IC50 = 11 nM) and pp60c-src (IC50 = 500 nM) with little effect on protein kinase A or protein kinase C (IC50 >200 µM). Also inhibits NMDA-stimulated cGMP production (IC50 = 30 nM). Exhibits anti-proliferative properties. Suppresses the angiogenic action of vascular endothelial growth factor in rats.
      FormOff-white solid
      CAS number125697-92-9
      Chemical formulaC₂₁H₁₉NO₆
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO or Ethanol (10 mg/ml). Further dilute with aqueous buffer just prior to use.
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesHu, D.E., and Fan, T.-P. 1995. Br. J. Pharmacol. 114, 262.
      Rodriguez, J., et al. 1994. Neuropharmacology 33, 1267.
      Hsu, C.-Y., et al. 1991. J. Biol. Chem. 266, 21105.
      O’Dell, T.J., et al. 1991. Nature 353, 558; Onoda, T., et al. 1989. J. Nat. Prod. 52, 1252.
      Bishop, J.M. 1983. Annu. Rev. Biochem. 52, 307.