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509306 Sigma-AldrichLate Endosome Trafficking Inhibitor, EGA - CAS 415687-81-9 - Calbiochem

A cell-permeable compound that prevents various bacterial toxins from exerting their cytotoxic activity by blocking endosomal trafficking/maturation into acidified late endosomes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 4-Bromobenzaldehyde-N-(2,6-dimethylphenyl)semicarbazone, (E)-2-(4-Bromobenzylidene)-N-(2,6-dimethylphenyl)hydrazinecarboxamide

Primary Target: host-membrane trafficking

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
415687-81-9	C₁₆H₁₆BrN₃O

价格及供货情况

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Description
Overview	A cell-permeable semicabazone compound that prevents B. anthrax Lethal toxin/LT (EC₅₀ = 1.7 µM in RAW264.7 cultures; EC_max = 6 µM in murine BMDM cultures), diphtheria toxin/DT, P. aeruginosa ExoA, and H. ducreyi cytolethal distending toxin (Hd-CDT) from exerting their cytotoxic activity, but not endocytic uptake, by blocking endosomal trafficking/maturation into acidified late endosomes, while exhibiting no cytoprotective efficacy against ricin & E. coli Ec-CDT that do not require acidified endosomes for intoxication. Likewise, EGA is also shown to inhibit low-pH-dependent viral infectivity by Armstrong strain of LCMV, A/WSN/33 strain of influenza virus, but not low-pH-independent infection of Nipah virus NiV or MLV. Although the exact molecular target remains unknown, EGA does not act as a pH neutralizing agent, nor does it inhibit endosomal recycling or trafficking to phagocytic compartments.
Catalogue Number	509306
Brand Family	Calbiochem®
Synonyms	4-Bromobenzaldehyde-N-(2,6-dimethylphenyl)semicarbazone, (E)-2-(4-Bromobenzylidene)-N-(2,6-dimethylphenyl)hydrazinecarboxamide

References
References	Gillespie, E.J., et al. 2013. Proc. Natl. Acad. Sci. USA 110, E4904.

Product Information
CAS number	415687-81-9
Form	Off-white powder
Hill Formula	C₁₆H₁₆BrN₃O
Chemical formula	C₁₆H₁₆BrN₃O
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	host-membrane trafficking
Purity	≥93% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.09306.0001	04055977241822

Documentation

Late Endosome Trafficking Inhibitor, EGA - CAS 415687-81-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Late Endosome Trafficking Inhibitor, EGA - CAS 415687-81-9 - Calbiochem 分析证书

标题	批号
509306	输入批号

参考

参考信息概述
Gillespie, E.J., et al. 2013. Proc. Natl. Acad. Sci. USA 110, E4904.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-March-2014 JSW
Synonyms	4-Bromobenzaldehyde-N-(2,6-dimethylphenyl)semicarbazone, (E)-2-(4-Bromobenzylidene)-N-(2,6-dimethylphenyl)hydrazinecarboxamide
Description	A cell-permeable semicarbazone compound that prevents B. anthrax Lethal toxin/LT (Protective Antigen/PA & LF/Lethal Factor complex; EC₅₀ = 1.7 µM in RAW264.7 cultures; EC_max = 6 µM in murine BMDM cultures), diphtheria toxin (DT), LF-DT A chain fusion LFnDTA/PA complex, P. aeruginosa ExoA, and H. ducreyi cytolethal distending toxin (Hd-CDT) from exerting their cytotoxic activity, but not endocytic uptake, by blocking endosomal trafficking/maturation into acidified late endosomes, while exhibiting no cytoprotective efficacy against toxins that do not require acidified endosomes for intoxication, such as ricin & E. coli Ec-CDT. Likewise, EGA is also shown to inhibit low-pH-dependent viral infectivity by Armstrong strain of LCMV, A/WSN/33 strain of influenza virus, vesicular stomatitis virus VSV-pseudotyped lentivirus & VSV-pseudotyped MLV, but not low-pH-independent infection of Nipah virus NiV or MLV. Although the exact molecular target remains unknown, EGA does not act as a pH neutralizing agent, nor does it inhibit endosomal recycling or trafficking to phagocytic compartments.
Form	Off-white powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	415687-81-9
Chemical formula	C₁₆H₁₆BrN₃O
Structure formula
Purity	≥93% by HPLC
Solubility	DMSO (5 mg/ml). Use only fresh DMSO for reconstitution.
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Gillespie, E.J., et al. 2013. Proc. Natl. Acad. Sci. USA 110, E4904.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Membrane Traffic Inhibitors

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