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427218 Sigma-AldrichLactate Dehydrogenase A Inhibitor, FX11 - Calbiochem

Lactate Dehydrogenase A Inhibitor, FX11, CAS 213971-34-7, is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: LDH-A Inhibitor I, LDH-M Inhibitor I, LDHM Inhibitor I, LDHA Inhibitor I

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概述

Replacement Information

价格及供货情况

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Description
Overview	A cell permeable, gossypol analog that acts as a selective, reversible, and NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; K_i = 8 µM for human liver LDHA). Does not affect the activities of LDHB and glyceraldehyde-3-phosphate dehydrogenase even at higher concentrations. Shown to increase oxygen consumption, reactive oxygen species production, and cell death in P493 human lymphoma B cells. Also shown to reduce mitochondrial transmembrane potential and ATP levels and increase AMP kinase activity. Exhibits synergistic toxicity in P493 cells when combined with FK866 (Cat. No. 481908). Blocks the progression of human lymphoma and pancreatic cancer xenografts and when used in combination with FK866 it induces lymphoma regression.
Catalogue Number	427218
Brand Family	Calbiochem®
Synonyms	LDH-A Inhibitor I, LDH-M Inhibitor I, LDHM Inhibitor I, LDHA Inhibitor I

References
References	Le, A., et al. 2011. Proc Natl Acad Sci USA. 107, 2037. Deck, L. M., et al. 1998. J Med Chem. 41, 3879.

Product Information
CAS number	213971-34-7
Form	White solid
Hill Formula	C₂₂H₂₂O₄
Chemical formula	C₂₂H₂₂O₄
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications
Application	Lactate Dehydrogenase A Inhibitor, FX11, CAS 213971-34-7, is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA).

Biological Information
Primary Target	LDHA
Primary Target K<sub>i</sub>	8 µ
Purity	≥96% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
427218-10MGCN	04055977187403

Documentation

Lactate Dehydrogenase A Inhibitor, FX11 - Calbiochem 分析证书

标题	批号
427218	输入批号

参考

参考信息概述
Le, A., et al. 2011. Proc Natl Acad Sci USA. 107, 2037. Deck, L. M., et al. 1998. J Med Chem. 41, 3879.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	18-December-2013 JSW
Synonyms	LDH-A Inhibitor I, LDH-M Inhibitor I, LDHM Inhibitor I, LDHA Inhibitor I
Description	A cell permeable, gossypol analog that acts as a selective, reversible, and NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; K_i = 8 µM for human liver LDHA). Does not affect the activities of LDHB and glyceraldehyde-3-phosphate dehydrogenase even at higher concentrations. Shown to increase oxygen consumption, reactive oxygen species production, and cell death in P493 human lymphoma B cells. Also shown to reduce mitochondrial transmembrane potential and ATP levels and increase AMP kinase activity. Exhibits synergistic toxicity in P493 cells when combined with FK866 (Cat. No. 481908). Blocks the progression of human lymphoma and pancreatic cancer xenografts and when used in combination with FK866 it induces lymphoma regression.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	213971-34-7
Chemical formula	C₂₂H₂₂O₄
Structure formula
Purity	≥96% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Le, A., et al. 2011. Proc Natl Acad Sci USA. 107, 2037. Deck, L. M., et al. 1998. J Med Chem. 41, 3879.

种类

Life Science Research > Inhibitors and Biochemicals

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