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426100 Sigma-AldrichLactacystin, Synthetic - CAS 1258004-00-0 - Calbiochem

Lactacystin, Synthetic, CAS 1258004-00-0, is an irreversible inhibitor of 20S proteasome inhibitor (IC₅₀ = 500 nM). A covalent inhibitor of the chymotrypsin & trypsin-like activities of proteasome.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

同义词: Proteasome Inhibitor VI

Primary Target: 20S proteasome (MCP; multicatalytic proteinase complex)

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
1258004-00-0	C₁₅H₂₄N₂O₇S

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
426100-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
426100-200UGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	200 μg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
426100-400UGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	400 μg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	An irreversible proteasome inhibitor. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP; multicatalytic proteinase complex) (IC₅₀ = 500 nM for 20S proteasome). Blocks proteasome activity by targeting the catalytic β-subunit. Acts as a covalent inhibitor of the chymotrypsin- and trypsin-like activities of the proteasome. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells and inhibits progression of synchronized Neuro 2A cells and MG-63 human osteosarcoma cells beyond the G₁ phase of the cell cycle. Reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC₅₀ = 10 µM).
Catalogue Number	426100
Brand Family	Calbiochem®
Synonyms	Proteasome Inhibitor VI

References
References	Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123. Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279. Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273. Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800. Fenteany, G., et al. 1995. Science 268, 726. Imajoh-Ohmi, S., et al. 1995. Biochem. Biophys. Res. Commun. 217, 1070. Jensen, T.J., et al. 1995. Cell 83, 129. Katagiri, M.M., et al. 1995. J. Antibiot. 48, 344. Mori, S., et al. 1995. J. Biol. Chem. 270, 29447. Tanaka, H., et al. 1995. Biochem. Biophys. Res. Commun. 216, 291. Fenteany, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3358. Omura, S., et al. 1991. J. Antibiot. 44, 117.

References

Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800.
Fenteany, G., et al. 1995. Science 268, 726.
Imajoh-Ohmi, S., et al. 1995. Biochem. Biophys. Res. Commun. 217, 1070.
Jensen, T.J., et al. 1995. Cell 83, 129.
Katagiri, M.M., et al. 1995. J. Antibiot. 48, 344.
Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
Tanaka, H., et al. 1995. Biochem. Biophys. Res. Commun. 216, 291.
Fenteany, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3358.
Omura, S., et al. 1991. J. Antibiot. 44, 117.

Product Information
CAS number	1258004-00-0
ATP Competitive	N
Form	White solid
Hill Formula	C₁₅H₂₄N₂O₇S
Chemical formula	C₁₅H₂₄N₂O₇S
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	20S proteasome (MCP; multicatalytic proteinase complex)
Primary Target IC<sub>50</sub>	500 nM against 20S proteasome; 10 µM against NF-κB activation
Purity	≥99% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Unstable in aqueous solutions; reconstitute in H₂O just prior to use.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
426100-1MGCN	04055977187311
426100-200UGCN	04055977187328
426100-400UGCN	04055977187335

Documentation

Lactacystin, Synthetic - CAS 1258004-00-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Lactacystin, Synthetic - CAS 1258004-00-0 - Calbiochem 分析证书

标题	批号
426100	输入批号

参考

参考信息概述
Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123. Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279. Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273. Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800. Fenteany, G., et al. 1995. Science 268, 726. Imajoh-Ohmi, S., et al. 1995. Biochem. Biophys. Res. Commun. 217, 1070. Jensen, T.J., et al. 1995. Cell 83, 129. Katagiri, M.M., et al. 1995. J. Antibiot. 48, 344. Mori, S., et al. 1995. J. Biol. Chem. 270, 29447. Tanaka, H., et al. 1995. Biochem. Biophys. Res. Commun. 216, 291. Fenteany, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3358. Omura, S., et al. 1991. J. Antibiot. 44, 117.

参考信息概述

小册子

标题
Caspases and other Apoptosis Related Tools Brochure
Proteasomes Technical Bulletin

引用

标题

Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.

Lacher, M.D., et al. 2006. Cancer Research 66, 1648.

Wu, C-J., et al. 2005. European Molecular Biology Organization Journal 24, 1886.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	23-October-2012 JSW
Synonyms	Proteasome Inhibitor VI
Description	An irreversible proteasome inhibitor. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP; multicatalytic proteinase complex) (IC₅₀ = 500 nM for 20S proteasome). Blocks proteasome activity by targeting the catalytic β-subunit. Acts as a covalent inhibitor of the chymotrypsin and trypsin-like activities of the proteasome. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells beyond theG1 phase of the cell cycle. Reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC₅₀ = 10 µM)
Form	White solid
CAS number	1258004-00-0
Chemical formula	C₁₅H₂₄N₂O₇S
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (50 mg/ml) or H₂O
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Unstable in aqueous solutions; reconstitute in H₂O just prior to use.
Toxicity	Standard Handling
References	Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123. Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279. Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273. Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800. Fenteany, G., et al. 1995. Science 268, 726. Imajoh-Ohmi, S., et al. 1995. Biochem. Biophys. Res. Commun. 217, 1070. Jensen, T.J., et al. 1995. Cell 83, 129. Katagiri, M.M., et al. 1995. J. Antibiot. 48, 344. Mori, S., et al. 1995. J. Biol. Chem. 270, 29447. Tanaka, H., et al. 1995. Biochem. Biophys. Res. Commun. 216, 291. Fenteany, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3358. Omura, S., et al. 1991. J. Antibiot. 44, 117.
Citation	Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123. Lacher, M.D., et al. 2006. Cancer Research 66, 1648. Wu, C-J., et al. 2005. European Molecular Biology Organization Journal 24, 1886.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Proteasome and Ubiquitination Pathway Inhibitors

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