数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

440205 Sigma-AldrichLY 83583 - CAS 91300-60-6 - Calbiochem

A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC₅₀ = 2 µM).

LY 83583 - CAS 91300-60-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: 6-Anilino-5,8-quinolinequinone

Primary Target: soluble guanylate cyclase

View Products on Sigmaaldrich.com

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
91300-60-6	C₁₅H₁₀N₂O₂

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
440205-5MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	5 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC₅₀ = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca²⁺ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors.
Catalogue Number	440205
Brand Family	Calbiochem®
Synonyms	6-Anilino-5,8-quinolinequinone

References
References	Adachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855. Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361. Beasley, D., et al. 1991. J. Clin. Invest. 87, 602. Pandol, S.J., et al. 1990. J. Biol. Chem. 265, 12846. Light, D.B., et al. 1989. Science 243, 383. Mulsch, A. 1988. J. Pharmacol. Exp. Ther. 247, 283. Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.

References

Adachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855.
Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361.
Beasley, D., et al. 1991. J. Clin. Invest. 87, 602.
Pandol, S.J., et al. 1990. J. Biol. Chem. 265, 12846.
Light, D.B., et al. 1989. Science 243, 383.
Mulsch, A. 1988. J. Pharmacol. Exp. Ther. 247, 283.
Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.

Product Information
CAS number	91300-60-6
ATP Competitive	N
Form	Reddish purple solid
Hill Formula	C₁₅H₁₀N₂O₂
Chemical formula	C₁₅H₁₀N₂O₂
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	soluble guanylate cyclase
Primary Target IC<sub>50</sub>	2 µM against soluble guanylate cyclase
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 22-36/37/38-45-46-48 Harmful if swallowed. Irritating to eyes, respiratory system and skin. May cause cancer. May cause heritable genetic damage. Danger of serious damage to health by prolonged exposure.
S Phrase	S: 22-26-36/37/39-45 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful & Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C or up to 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
440205-5MGCN	04055977186727

Documentation

LY 83583 - CAS 91300-60-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

LY 83583 - CAS 91300-60-6 - Calbiochem 分析证书

标题	批号
440205	输入批号

参考

参考信息概述
Adachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855. Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361. Beasley, D., et al. 1991. J. Clin. Invest. 87, 602. Pandol, S.J., et al. 1990. J. Biol. Chem. 265, 12846. Light, D.B., et al. 1989. Science 243, 383. Mulsch, A. 1988. J. Pharmacol. Exp. Ther. 247, 283. Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.

参考信息概述

小册子

标题
Pathways and Biomarkers of Oxidative Stress

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	01-February-2024 JSW
Synonyms	6-Anilino-5,8-quinolinequinone
Description	A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC₅₀ = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca²⁺ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells.
Form	Reddish purple solid
CAS number	91300-60-6
Chemical formula	C₁₅H₁₀N₂O₂
Structure formula
Purity	≥98% by HPLC
Solubility	Acetone or Ethanol (3 mg/ml)
Storage	+2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C or up to 6 months at -20°C.
Toxicity	Harmful & Carcinogenic / Teratogenic
References	Adachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855. Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361. Beasley, D., et al. 1991. J. Clin. Invest. 87, 602. Pandol, S.J., et al. 1990. J. Biol. Chem. 265, 12846. Light, D.B., et al. 1989. Science 243, 383. Mulsch, A. 1988. J. Pharmacol. Exp. Ther. 247, 283. Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Nitric Oxide and Oxidative Stress > Guanylate Cyclase Inhibitors

此产品已添加到您的购物车。