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440202 Sigma-AldrichLY 294002 - CAS 154447-36-6 - Calbiochem

LY294002, CAS 154447-36-6, is a cell-permeable, potent, reversible, and specific inhibitor of PI 3-kinase ((IC₅₀ = 1.4 µM). Acts on the ATP-binding site.

LY 294002 - CAS 154447-36-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
技术信息
数据表
Data Sheet
Citations
Posters

同义词: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV

Primary Target: Phosphatidylinositol 3-kinase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
154447-36-6	C₁₉H₁₇NO₃

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
440202-10MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	10 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
440202-25MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	25 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
440202-5MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	5 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A cell-permeable, potent, reversible and specific phosphatidylinositol 3-kinase inhibitor (IC₅₀ = 1.4 µM) that acts on the ATP-binding site of the enzyme. Also inhibits nonhomologous DNA end-joining (NHEJ) activity of the 460 kDa phosphatidylinositol 3-like kinase DNA-PKc_s, which is the catalytic subunit of DNA-activated protein kinase. Does not affect the activities of EGF receptor kinase, MAP kinase, PKC, Pl 4-kinase, S6 kinase, and c-Src even at 50 µM. Promotes the nuclear accumulation of active GSK-3b. Reported to suppress the proliferation of murine embryonic stem cells. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis. Shown to bind to the same site as I-BET (Cat. No. 40101050 ~ 10 µM). A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440204) in DMSO is also available.
Catalogue Number	440202
Brand Family	Calbiochem®
Synonyms	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV

References
References	Dittman, A., et al. 2013. ACS Chem. Biol. 9, 495. Bechard, M., and Dalton. S. 2009. Mol. Cell. Biol. 29, 2092. Lianguzova, M.S. et al. 2007. Cell Biol. Int. 31, 330. Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066. Cardone, M.H., et al. 1998. Science 282, 1318. Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413. Yano, H., et al. 1995. Biochem. J. 312, 145. Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76.

References

Dittman, A., et al. 2013. ACS Chem. Biol. 9, 495.
Bechard, M., and Dalton. S. 2009. Mol. Cell. Biol. 29, 2092.
Lianguzova, M.S. et al. 2007. Cell Biol. Int. 31, 330.
Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066.
Cardone, M.H., et al. 1998. Science 282, 1318.
Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413.
Yano, H., et al. 1995. Biochem. J. 312, 145.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.

Selected Citations
Lee, J., et al. 2009. Cell Stem Cell 5, 76.

Product Information
CAS number	154447-36-6
ATP Competitive	Y
Form	Off-white solid
Hill Formula	C₁₉H₁₇NO₃
Chemical formula	C₁₉H₁₇NO₃
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Phosphatidylinositol 3-kinase
Primary Target IC<sub>50</sub>	1.4 µM against phosphatidylinositol 3-kinase
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
440202-10MGCN	04055977186666
440202-25MGCN	04055977186673
440202-5MGCN	07790788050290

Documentation

LY 294002 - CAS 154447-36-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

LY 294002 - CAS 154447-36-6 - Calbiochem 分析证书

标题	批号
440202	输入批号

参考

参考信息概述
Dittman, A., et al. 2013. ACS Chem. Biol. 9, 495. Bechard, M., and Dalton. S. 2009. Mol. Cell. Biol. 29, 2092. Lianguzova, M.S. et al. 2007. Cell Biol. Int. 31, 330. Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066. Cardone, M.H., et al. 1998. Science 282, 1318. Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413. Yano, H., et al. 1995. Biochem. J. 312, 145. Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76.

参考信息概述

小册子

标题
An Introduction to Inhibitors and Their Biological Applications - 1st Edition
Bulk Product Guide

技术信息

标题
JAK/STAT Signaling Research Focus

数据表

标题
Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation

海报

标题
Human Kinome & InhibitorSelect™ Libraries

引用

标题

Bechard, M., and Dalton. S. 2009. Mol. Cell. Biol. 29, 2092.

Lianguzova, M.S. et al. 2007. Cell Biol. Int. 31, 330.

Oliveira, J.B., et al. 2007. Procedings of the National Academy of Science 104, 8953.

Satoshi Fukumoto, et al. (2006) Laminin 5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. Journal of Biological Chemistry 281, 5008-5016.

Ana Olivera, et al. (2006) IgE-dependent activation of sphingosine kinase 1 and 2 and secretion of sphingosine-1-phosphate requires Fyn kinase and contributes to mast cell responses. Journal of Biological Chemistry 281, 2515-2525.

Qian Yang, et al. (2006) TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proceedings of the National Academy of Sciences (USA) 103, 6811-6816.

Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.

Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.

Julie Lotharius, et al. (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed lineage kinase pathway. Journal of Neuroscience 25, 6329-6342.

Meenalakshmi M. Mariappan, M.M., et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.

Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,.

Junji Tsurutani, et al. (2005) Inhibition of the phosphatidylinositol 3-kinase/Akt/Mammalian target of rapamycin pathway but no the MEK/ERK Pathway attentuates laminin-meidated small cell lunch cancer cellular survival and resistance to Imatinib mesylate or chemolyte.. Cancer Research 65, 8423-8432.

Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-February-2012 RFH
Synonyms	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV
Description	A cell-permeable, potent, reversible, and specific phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor that acts on the ATP-binding site of the enzyme (IC₅₀ = 1.4 µM). Also inhibits nonhomologous DNA end-joining (NHED) in the 460 kDa phosphatidylinositol 3-like kinase DNA-PK_cs, which is the catalytic subunit of DNA-activated protein kinase. Does not affect the activity of EGF receptor kinase, MAP kinase, PKC, PI 4-kinase, S6 kinase, and c-src at 50 µM. Promotes the nuclear accumulation of active GSK-3b. Reported to suppress the proliferation of murine embryonic stem cells. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis. Reported to inhibit histamine secretion in RBL-2H3 cells (IC₅₀ = 5 µM).
Form	Off-white solid
CAS number	154447-36-6
Chemical formula	C₁₉H₁₇NO₃
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (20 mg/ml) or Ethanol. Slight warming may be required to achieve complete solubilization.
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Dittman, A., et al. 2013. ACS Chem. Biol. 9, 495. Bechard, M., and Dalton. S. 2009. Mol. Cell. Biol. 29, 2092. Lianguzova, M.S. et al. 2007. Cell Biol. Int. 31, 330. Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066. Cardone, M.H., et al. 1998. Science 282, 1318. Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413. Yano, H., et al. 1995. Biochem. J. 312, 145. Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76.
Citation	Bechard, M., and Dalton. S. 2009. Mol. Cell. Biol. 29, 2092. Lianguzova, M.S. et al. 2007. Cell Biol. Int. 31, 330. Oliveira, J.B., et al. 2007. Procedings of the National Academy of Science 104, 8953. Satoshi Fukumoto, et al. (2006) Laminin 5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. Journal of Biological Chemistry 281, 5008-5016. Ana Olivera, et al. (2006) IgE-dependent activation of sphingosine kinase 1 and 2 and secretion of sphingosine-1-phosphate requires Fyn kinase and contributes to mast cell responses. Journal of Biological Chemistry 281, 2515-2525. Qian Yang, et al. (2006) TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proceedings of the National Academy of Sciences (USA) 103, 6811-6816. Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761. Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385. Julie Lotharius, et al. (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed lineage kinase pathway. Journal of Neuroscience 25, 6329-6342. Meenalakshmi M. Mariappan, M.M., et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411. Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,. Junji Tsurutani, et al. (2005) Inhibition of the phosphatidylinositol 3-kinase/Akt/Mammalian target of rapamycin pathway but no the MEK/ERK Pathway attentuates laminin-meidated small cell lunch cancer cellular survival and resistance to Imatinib mesylate or chemolyte.. Cancer Research 65, 8423-8432. Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Phosphatidylinositol 3-Kinase (PI 3-kinase) Inhibitors

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