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A cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding
activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC50 = 2.1 µM in NIH 3T3 cells).
Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI50 = 3.8, 0.79, and 6.3
µM in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell
lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular
carcinoma s.c. growth in mouse xenograft model without any toxic effects (1 mg/kg, i.p., once every 3 days).
Grant, T.J., et al. 2012. Proc. Natl. Acad. Sci. USA109, 4503.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding
activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC50 = 2.1 µM in NIH 3T3 cells).
Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI50 = 3.8, 0.79, and 6.3
µM in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell
lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular
carcinoma s.c. growth in mouse xenograft model without any toxic effects (1 mg/kg, i.p., once every 3 days).
Form
White powder
Intert gas (Yes/No)
Packaged under inert gas
Chemical formula
C₁₈H₁₇NO₄
Purity
>92% by HPLC
Solubility
DMSO (100 mg/ml)
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity
Standard Handling
References
Grant, T.J., et al. 2012. Proc. Natl. Acad. Sci. USA109, 4503.
