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428201 LDN-211904 - CAS 1198408-78-4 - Calbiochem

LDN-211904 modulates the biological activity of EphB3 receptor tyrosine kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

LDN-211904 - CAS 1198408-78-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: N-(2-chlorophenyl)-6-(piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide oxalate, EphB3 inhibitor, LDN-211904

Primary Target: Erythropoietin-producing hepatocellular carcinoma (Eph)
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428201
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概述

重要规格表

CAS #Empirical Formula
1198408-78-4C₂₁H₂₁ClN₄O₅

价格及供货情况

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428201-5MGCN
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      		 玻璃瓶 5 mg
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      Description
      OverviewA pyrazolo[1,5-a]pyridine derivative that acts as an potent and reversible EphB3 receptor tyrosine kinase inhibitor with an IC50 of 79 nM with good mouse liver microsomal stability and aqueous solubility. Shown to suppress EphB3-induced autophosphorylation of EphB3 receptor at 10 µM in cells. When profiled against a panel of 288 kinases at 5 µM, found to also inhibit most of the Eph (Erythropoietin-producing hepatocellular carcinoma) receptor kinases including EphA1, EphA2, EphA3, EphA4, EphA5, EphA8, EphB1, EphB2, EphB3, EphB4 and other tyrosine kinases, but not EphA6 and EphA7, and is non-inhibitory towards non-RTK kinases screened except for p38α, p38β, and Qik.
      Catalogue Number428201
      Brand Family Calbiochem®
      SynonymsN-(2-chlorophenyl)-6-(piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide oxalate, EphB3 inhibitor, LDN-211904
      References
      ReferencesQiao, L., et al. 2011, Bioorg. Med. Chem. Lett. 19, 6122
      Product Information
      CAS number1198408-78-4
      FormOff-white solid
      Hill FormulaC₂₁H₂₁ClN₄O₅
      Chemical formulaC₂₁H₂₁ClN₄O₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetErythropoietin-producing hepatocellular carcinoma (Eph)
      Primary Target IC<sub>50</sub>79 nM
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      产品目录编号 GTIN
      428201-5MGCN 04055977210064