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524644 Sigma-AldrichL-α-Phosphatidyl-D-myo-inositol-4,5-bisphosphate, Triammonium Salt, Porcine Brain - CAS 383907-42-4 - Calbiochem

A component of membrane-bound receptors in association with phospholipase C (PLC).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: PIP₂

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
383907-42-4	C₄₇H₈₂O₁₉P₃ · 3NH₄

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
524644-100UGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	100 μg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
524644-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A component of membrane-bound receptors in association with phospholipase C (PLC). Potently stimulates brain phospholipase D (PLD) activity in vitro. Has been shown to activate protein kinase C (PKC) in the presence of phosphatidylserine and Ca²⁺. Antagonist of ATP-sensitive potassium (K_ATP) channels when applied to inside-out membrane patches.
Catalogue Number	524644
Brand Family	Calbiochem®
Synonyms	PIP₂

References
References	Baukrowitz, T., et al. 1998. Science 282, 1141. Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138. Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181. Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403. Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852. Williamson, J.R. 1986. Hypertension 8, 140. Berridge, M.J., and Irvine, R.F. 1984. Nature 312, 315.

References

Baukrowitz, T., et al. 1998. Science 282, 1141.
Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138.
Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181.
Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403.
Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852.
Williamson, J.R. 1986. Hypertension 8, 140.
Berridge, M.J., and Irvine, R.F. 1984. Nature 312, 315.

Product Information
CAS number	383907-42-4
ATP Competitive	N
Form	White to off-white solid
Hill Formula	C₄₇H₈₂O₁₉P₃ · 3NH₄
Chemical formula	C₄₇H₈₂O₁₉P₃ · 3NH₄
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Brain phospholipase D (PLD)
Purity	≥98% by TLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Irritant
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution in H₂O, store in the refrigerator (4°C). Do not freeze aqueous solutions. Following reconstitution in chloroform, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 days at 4°C. Chloroform stock solutions are stable for up to 1 month at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
524644-100UGCN	04055977197624
524644-1MGCN	04055977197617

Documentation

L-α-Phosphatidyl-D-myo-inositol-4,5-bisphosphate, Triammonium Salt, Porcine Brain - CAS 383907-42-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

L-α-Phosphatidyl-D-myo-inositol-4,5-bisphosphate, Triammonium Salt, Porcine Brain - CAS 383907-42-4 - Calbiochem 分析证书

标题	批号
524644	输入批号

参考

参考信息概述
Baukrowitz, T., et al. 1998. Science 282, 1141. Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138. Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181. Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403. Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852. Williamson, J.R. 1986. Hypertension 8, 140. Berridge, M.J., and Irvine, R.F. 1984. Nature 312, 315.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	03-August-2015 JSW
Synonyms	PIP₂
Description	A component of membrane-bound receptors in association with phospholipase C. Hydrolysis of PIP₂ yields IP₃ and diacylglycerol, causing the release of intracellular Ca²⁺ and activation of protein kinase C. Potently stimulates phospholipase D activity in vitro in brain tissue. A substrate for PI 3-kinase. Antagonist of ATP inhibtion of ATP-sensitive potassium (K_ATP) channels when applied to inside-out membrane patches. Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.
Form	White to off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	383907-42-4
Chemical formula	C₄₇H₈₂O₁₉P₃ · 3NH₄
Structure formula
Purity	≥98% by TLC
Solubility	CHCl₃ (50 mg/ml) or H₂O (10 mg/ml)
Storage	Protect from light ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution in H₂O, store in the refrigerator (4°C). Do not freeze aqueous solutions. Following reconstitution in chloroform, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 days at 4°C. Chloroform stock solutions are stable for up to 1 month at -20°C.
Toxicity	Irritant
References	Baukrowitz, T., et al. 1998. Science 282, 1141. Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138. Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181. Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403. Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852. Williamson, J.R. 1986. Hypertension 8, 140. Berridge, M.J., and Irvine, R.F. 1984. Nature 312, 315.

种类

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Lipids > Phosphoinositides, Phospholipids and Related Products

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