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400600 L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride - CAS 159190-44-0 - Calbiochem

概述

Replacement Information

重要规格表

CAS #Empirical Formula
159190-44-0C₇H₁₅N₃O₂ · 2HCl

价格及供货情况

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400600-20MGCN
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      塑胶安瓿;塑胶针药瓶 20 mg
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      Description
      OverviewA cell-permeable, more potent inhibitor of endothelial nitric oxide synthase (eNOS; IC50 = 500 nM) compared to other arginine analogs such as L-NAME (Cat. No. 483125) and L-NMMA (Cat. No. 475886). Inhibits acetylcholine-induced relaxation of rat aorta rings (IC50 = 2 µM) and causes a dose-dependent increase in mean arterial blood pressure in the rat (EC50 = 19.5 mg/kg).
      Catalogue Number400600
      Brand Family Calbiochem®
      SynonymsL-NIO, 2HCl
      References
      ReferencesMoore, W.M., et al. 1994. J. Med. Chem. 37, 3886.
      Rees, D.D., et al. 1990. Br. J. Pharmacol. 101, 746.
      Product Information
      CAS number159190-44-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₇H₁₅N₃O₂ · 2HCl
      Chemical formulaC₇H₁₅N₃O₂ · 2HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargeteNOS
      Primary Target IC<sub>50</sub>500 nM against endothelial nitric oxide synthase (eNOS); 2 µM against acetylcholine-induced relaxation of rat aorta rings; EC50 = 19.5 mg/kg for a dose-dependent increase in mean arterial blood pressure in the rat
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      400600-20MGCN 04055977189346

      Documentation

      L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride - CAS 159190-44-0 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride - CAS 159190-44-0 - Calbiochem 分析证书

      标题批号
      400600

      参考

      参考信息概述
      Moore, W.M., et al. 1994. J. Med. Chem. 37, 3886.
      Rees, D.D., et al. 1990. Br. J. Pharmacol. 101, 746.

      小册子

      标题
      Pathways and Biomarkers of Oxidative Stress
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-April-2011 RFH
      SynonymsL-NIO, 2HCl
      DescriptionCell permeable. Approximately five times more potent as an inhibitor of endothelial nitric oxide synthase (IC50 = 500 nM) than other arginine analogs, such as L-NAME (Cat. No. 483125) and L-NMMA (Cat. No. 475886). Inhibits acetylcholine induced relaxation of rat aorta rings (IC50 = 2 µM) and causes a dose-dependent increase in mean arterial blood pressure in the rat (EC50 = 19.5 mg/kg).
      FormWhite solid
      CAS number159190-44-0
      Chemical formulaC₇H₁₅N₃O₂ · 2HCl
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Irritant
      ReferencesMoore, W.M., et al. 1994. J. Med. Chem. 37, 3886.
      Rees, D.D., et al. 1990. Br. J. Pharmacol. 101, 746.