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422175 Sigma-AldrichL-165,041 - CAS 79558-09-1 - Calbiochem

A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (K_i = 6 nM for hPPARδ and 730 nM for hPPARγ).

L-165,041 - CAS 79558-09-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Compound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII

Primary Target: Peroxisome proliferator activator receptor δ (PPAR@delta;)

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
79558-09-1	C₂₂H₂₆O₇

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Description
Overview	A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (K_i = 6 nM for hPPARδ and 730 nM for hPPARγ). Potently induces adipocyte differentiation in NIH-PPARδ cells at 500 nM and raises total cholesterol in insulin resistant db/db mice without altering glucose or triglycerides levels. Increases UCP3 (uncoupling protein 3) gene expression in L6 myotubes. Inhibits cytokine-induced expression of VCAM-1 (vascular cell adhesion molecule-1) and the secretion of MCP-1 (monocyte chemotactic protein-1) in EAhy926 cells.
Catalogue Number	422175
Brand Family	Calbiochem®
Synonyms	Compound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII

References
References	Rival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143. Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082. Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175. Son, C., et al. 2001. Endocrinology 142, 4189. Wilkie, N., et al. 2001. J. Neurochem. 78, 1135. Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333. Berger, J., et al. 1999. J. Biol. Chem. 274, 6718. Lim, H., et al. 1999. Genes Dev. 13, 1561.

References

Rival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143.
Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082.
Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175.
Son, C., et al. 2001. Endocrinology 142, 4189.
Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333.
Berger, J., et al. 1999. J. Biol. Chem. 274, 6718.
Lim, H., et al. 1999. Genes Dev. 13, 1561.

Product Information
CAS number	79558-09-1
ATP Competitive	N
Form	White solid
Hill Formula	C₂₂H₂₆O₇
Chemical formula	C₂₂H₂₆O₇
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Peroxisome proliferator activator receptor δ (PPAR@delta;)
Primary Target K<sub>i</sub>	6 nM for hPPARδ and 730 nM for hPPARγ
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
422175-5MGCN	04055977187144

Documentation

L-165,041 - CAS 79558-09-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

L-165,041 - CAS 79558-09-1 - Calbiochem 分析证书

标题	批号
422175	输入批号

参考

参考信息概述
Rival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143. Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082. Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175. Son, C., et al. 2001. Endocrinology 142, 4189. Wilkie, N., et al. 2001. J. Neurochem. 78, 1135. Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333. Berger, J., et al. 1999. J. Biol. Chem. 274, 6718. Lim, H., et al. 1999. Genes Dev. 13, 1561.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	05-August-2008 RFH
Synonyms	Compound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII
Description	A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (K_i = 6 nM for hPPAR δ and 730 nM for hPPARγ). Induces adipocyte differentiation in NIH-PPARδ cells at 500 nM. Also reported to raise total cholesterol in insulin-resistant db/db mice without altering glucose or triglyceride levels. Shown to increase uncoupling protein 3 (UCP3) gene expression in L6 myotubes. Also shown to inhibit cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) and the secretion of monocyte chemotactic protein-1 (MCP-1) in Eahy926 cells.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	79558-09-1
Chemical formula	C₂₂H₂₆O₇
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (5 mg/ml) or 1 N NaOH (40 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Irritant
References	Rival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143. Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082. Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175. Son, C., et al. 2001. Endocrinology 142, 4189. Wilkie, N., et al. 2001. J. Neurochem. 78, 1135. Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333. Berger, J., et al. 1999. J. Biol. Chem. 274, 6718. Lim, H., et al. 1999. Genes Dev. 13, 1561.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Peroxisome Proliferator Activated Receptor (PPAR) Agonists

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422175 Sigma-AldrichL-165,041 - CAS 79558-09-1 - Calbiochem

A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (K_i = 6 nM for hPPARδ and 730 nM for hPPARγ).

同义词: Compound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII

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概述

重要规格表

价格及供货情况

Documentation

L-165,041 - CAS 79558-09-1 - Calbiochem MSDS

L-165,041 - CAS 79558-09-1 - Calbiochem 分析证书

参考

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A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (Ki = 6 nM for hPPARδ and 730 nM for hPPARγ).

同义词: Compound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII

Recommended Products

重要规格表

价格及供货情况

L-165,041 - CAS 79558-09-1 - Calbiochem MSDS

L-165,041 - CAS 79558-09-1 - Calbiochem 分析证书

参考

种类

最近查看的内容

A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (K_i = 6 nM for hPPARδ and 730 nM for hPPARγ).