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Native, single chain, high molecular weight Kininogen from human plasma. Nonenzymatic cofactor of the contact activation system. Links prekallikrein to negatively charged surfaces, thereby allowing activation to kallikrein by surface-bound Factor α-XIIa. Also circulates in plasma in complex with Factor XI and may play a role in the activation of Factor XI to Factor XIa by Factor α-XIIa. Serves as a source of bradykinin, a potent vasoactive peptide important in hypotension studies.
Catalogue Number
422686
Brand Family
Calbiochem®
References
References
Weisel, J.W., et al. 1994. J. Biol. Chem. 269, 10100.
Product Information
Form
Liquid
Formulation
In 150 mM NaCl, 4 mM sodium acetate buffer, pH 5.3.
Kininogen, High Molecular Weight, Single Chain, Human Plasma - Calbiochem 分析证书
标题
批号
422686
参考
参考信息概述
Weisel, J.W., et al. 1994. J. Biol. Chem. 269, 10100.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
05-August-2008 RFH
Description
Native, single chain, high molecular weight Kininogen from human plasma. Non-enzymatic cofactor of the contact activation system. Links prekallikrein to negatively charged surfaces, thereby allowing activation to kallikrein by surface-bound Factor a-XIIa. Also circulates in plasma in complex with Factor XI, that may play a role in the activation of Factor XI to Factor XIa by Factor α-XIIa. Serves as a source of bradykinin, a potent vasoactive peptide important in hypotension studies.
Form
Liquid
Formulation
In 150 mM NaCl, 4 mM sodium acetate buffer, pH 5.3.
Concentration Label
Please refer to vial label for lot-specific concentration
Source
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Purity
≥95% by SDS-PAGE
Storage
Avoid freeze/thaw
≤ -70°C
Do Not Freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-70°C).
Toxicity
Standard Handling
References
Weisel, J.W., et al. 1994. J. Biol. Chem. 269, 10100.
