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A selective 5-HT2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT2AR (Ki = 1.49 nM) relative to other family members like 5-HT2BR (Ki = 740 nM) and 5-HT2CR (Ki = 59 nM). Often used in conjunction with SB 206553 to distinguish 5-HT2AR and 5-HT2CR activity.
Catalogue Number
506271
Brand Family
Calbiochem®
Synonyms
5-HT2A Serotonin Receptor Antagonist, Ketanserin, R 41 468
References
References
Ros, R. et al. 2013. PNAS.110, 348. Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114. Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol.406, 163. Leysen, J. E. et al. 1981. Life Sci.28, 1015.
If swallowed, seek medical advice immediately and show this container or label.
Product Usage Statements
Storage and Shipping Information
Ship Code
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
5.06271.0001
04055977243192
Documentation
Ketanserin Tartrate - CAS 83846-83-7 - Calbiochem MSDS
Ros, R. et al. 2013. PNAS.110, 348. Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114. Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol.406, 163. Leysen, J. E. et al. 1981. Life Sci.28, 1015.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
27-September-2013 JSW
Synonyms
5-HT2A Serotonin Receptor Antagonist, Ketanserin, R 41 468
Description
A selective 5-HT2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT2AR (Ki = 1.49 nM) relative to other family members like 5-HT2BR (Ki = 740 nM) and 5-HT2CR (Ki = 59 nM). Often used in conjunction with SB 206553 to distinguish 5-HT2AR and 5-HT2CR activity.
Form
White solid
CAS number
83846-83-7
Chemical formula
C₂₂H₂₂FN₃O₃·C₄H₆O₆
Structure formula
Purity
≥97% by HPLC
Solubility
DMSO
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Toxic
References
Ros, R. et al. 2013. PNAS.110, 348. Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114. Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol.406, 163. Leysen, J. E. et al. 1981. Life Sci.28, 1015.
