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420345 Sigma-AldrichKaempferol - CAS 520-18-3 - Calbiochem

A cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells.

Kaempferol - CAS 520-18-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: 3,4ʹ,5,7-Tetrahydroxyflavone

Primary Target: Topoisomerase I-catalyzed DNA religation in HL-60 cells

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
520-18-3	C₁₅H₁₀O₆

价格及供货情况

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Description
Overview	A cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Offers protection against Aβ_25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Blocks the Aβ-induced activation of caspase-2, -3, -8, and -9, and reduces NMDA-induced neuronal apoptosis. Reported to be a potent inhibitor of monoamine oxidases. Acts as an inhibitor of COX-1 activity (IC₅₀ = 180 µM), and of transcriptional activation of COX-2 (IC₅₀<15 µM).
Catalogue Number	420345
Brand Family	Calbiochem®
Synonyms	3,4ʹ,5,7-Tetrahydroxyflavone

References
References	Wang, C.N., et al. 2001. J. Biol. Chem. 276, 5287. Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451. Wang, H., et al. 2000. Phytomedicine 7, 15. Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945. Roth, A., et al. 1999. J. Neurosci. Res. 57, 399. Boege, F., et al. 1996. J. Biol. Chem. 271, 2262. Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.

Product Information
CAS number	520-18-3
ATP Competitive	N
Form	Yellow solid
Hill Formula	C₁₅H₁₀O₆
Chemical formula	C₁₅H₁₀O₆
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Topoisomerase I-catalyzed DNA religation in HL-60 cells
Primary Target IC<sub>50</sub>	180 µM against COX-1 activity
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	LK9275200

Safety Information
R Phrase	R: 36/37/38-40 Irritating to eyes, respiratory system and skin. Limited evidence of a carcinogenic effect.
S Phrase	S: 22-26-36 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
420345-25MGCN	04055977187502

Documentation

Kaempferol - CAS 520-18-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Kaempferol - CAS 520-18-3 - Calbiochem 分析证书

标题	批号
420345	输入批号

参考

参考信息概述
Wang, C.N., et al. 2001. J. Biol. Chem. 276, 5287. Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451. Wang, H., et al. 2000. Phytomedicine 7, 15. Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945. Roth, A., et al. 1999. J. Neurosci. Res. 57, 399. Boege, F., et al. 1996. J. Biol. Chem. 271, 2262. Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.

小册子

标题
Alzheimer's Disease Brochure & Technical Guide
Caspases and other Apoptosis Related Tools Brochure

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	02-January-2008 JSW
Synonyms	3,4ʹ,5,7-Tetrahydroxyflavone
Description	A cell-permeable, phytoestrogen that offers protection against Aβ_25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Reduces the activation of caspases 2, 3, 8, and 9 by Aβ. Inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Also shown to protect against NMDA-induced neuronal toxicity in vitro in cultured rat cortical neurons. Acts as an inhibitor of cyclooxygenases (COX-1, IC₅₀ = 180 µM) and COX-2 (IC₅₀ = ~15 µM).
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	520-18-3
RTECS	LK9275200
Chemical formula	C₁₅H₁₀O₆
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (25 mg/ml) or Ethanol (20 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
Merck USA index	14, 5274
References	Wang, C.N., et al. 2001. J. Biol. Chem. 276, 5287. Sloley, B.D., et al. 2000. J. Pharm. Pharmacol. 52, 451. Wang, H., et al. 2000. Phytomedicine 7, 15. Liang, Y.C., et al. 1999. Carcinogenesis 20, 1945. Roth, A., et al. 1999. J. Neurosci. Res. 57, 399. Boege, F., et al. 1996. J. Biol. Chem. 271, 2262. Constantinou, A., et al. 1995. J. Nat. Prod. 58, 217.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Cyclooxygenase (COX) Inhibitors

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