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Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology289, H414-H425.
Bing Zhu, Samuel Strada and Troy Stevens. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology289, L196-L206.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
30-July-2008 RFH
Synonyms
PKG Inhibitor VII
Description
Highly specific cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (Ki = 234 nM). Inhibits protein kinase C (Ki = 4.0 µM) and protein kinase A (Ki > 10.0 µM) at higher concentrations.
Form
White solid
CAS number
126643-37-6
Chemical formula
C₂₉H₂₅N₃O₅
Structure formula
Purity
≥98% by HPLC
Solubility
DMF or DMSO (1 mg/ml). Further dilute with aqueous buffers just prior to use.
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity
Standard Handling
References
Grider, J.R. 1993. Am. J. Physiol.264, G334.
Citation
Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology289, H414-H425.
Bing Zhu, Samuel Strada and Troy Stevens. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology289, L196-L206.