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422711 KN-93, Water-Soluble - Calbiochem

This KN-93 is a water-soluble version of KN-93 that acts as a reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM for rat brain).

KN-93, Water-Soluble - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Calmodulin-Dependent Protein Kinase (CaM Kinase) 2
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422711
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概述

Replacement Information

重要规格表

Empirical Formula
C₂₆H₂₉ClN₂O₄S · H₃PO₄

价格及供货情况

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      Description
      OverviewA water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Also available as a 5 mM solution in H2(Cat. No. 508315).
      Catalogue Number422711
      Brand Family Calbiochem®
      References
      ReferencesTombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
      Chen, C., et al. 1994. Science 266, 291.
      Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
      Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
      Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₆H₂₉ClN₂O₄S · H₃PO₄
      Chemical formulaC₂₆H₂₉ClN₂O₄S · H₃PO₄
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCalmodulin-Dependent Protein Kinase (CaM Kinase) 2
      Primary Target K<sub>i</sub>370 nM for cam kinase 2
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      422711-1MGCN 04055977187274

      Documentation

      KN-93, Water-Soluble - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      KN-93, Water-Soluble - Calbiochem 分析证书

      标题批号
      422711

      参考

      参考信息概述
      Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
      Chen, C., et al. 1994. Science 266, 291.
      Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
      Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
      Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-August-2008 RFH
      DescriptionA water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
      FormWhite solid
      Chemical formulaC₂₆H₂₉ClN₂O₄S · H₃PO₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesTombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
      Chen, C., et al. 1994. Science 266, 291.
      Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
      Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
      Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

      相关产品和应用

      Alternative Products

      产品目录编号 描述  
      422708 KN-93 - CAS 139298-40-1 - Calbiochem 显示价格及库存情况

      种类

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors