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422708 Sigma-AldrichKN-93 - CAS 139298-40-1 - Calbiochem

KN-93, CAS 139298-40-1, is a cell-permeable, reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM). Binds to the CaM binding site and prevents the association of CaM with CaMKII.

KN-93 - CAS 139298-40-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: 2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine)

Primary Target: cam kinase 2

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
139298-40-1	C₂₆H₂₉CIN₂O₄S

价格及供货情况

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Description
Overview	A cell-permeable, reversible and competitive inhibitor of rat brain CaM kinase II (K_i = 370 nM). Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effects on protein kinase A activity. Induces G₁ cell cycle arrest and apoptosis in NIH/3T3 cells. A 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422712) in DMSO is also available.
Catalogue Number	422708
Brand Family	Calbiochem®
Synonyms	2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine)

References
References	Fan, G.H., et al. 1999. Mol. Pharmacol. 56, 39. Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063. Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608. Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255. Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968. Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

Product Information
CAS number	139298-40-1
ATP Competitive	Y
Form	Off-white solid
Hill Formula	C₂₆H₂₉CIN₂O₄S
Chemical formula	C₂₆H₂₉CIN₂O₄S
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications
Application	KN-93, CAS 139298-40-1, is a cell-permeable, reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM). Binds to the CaM binding site and prevents the association of CaM with CaMKII.

Biological Information
Primary Target	cam kinase 2
Primary Target K<sub>i</sub>	370 nM against rat brain CaM kinase II
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
422708-1MGCN	04055977187243
422708-5MGCN	04055977187250

Documentation

KN-93 - CAS 139298-40-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

KN-93 - CAS 139298-40-1 - Calbiochem 分析证书

标题	批号
422708	输入批号

参考

参考信息概述
Fan, G.H., et al. 1999. Mol. Pharmacol. 56, 39. Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063. Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608. Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255. Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968. Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	25-November-2009 RFH
Synonyms	2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine)
Description	Cell-permeable, reversible, and competitive inhibitor of rat brain Ca⁺²/calmodulin-dependent protein kinase II (K_i = 370 nM). KN-93 selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Selectively binds to the CaM binding site of the enzyme and prevents the association of CaM with CaMKII. Has no significant effect on protein kinase A activity. Induces G₁ cell cycle arrest and apoptosis in NIH 3T3 cells.
Form	Off-white solid
CAS number	139298-40-1
Chemical formula	C₂₆H₂₉CIN₂O₄S
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity	Irritant
References	Fan, G.H., et al. 1999. Mol. Pharmacol. 56, 39. Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063. Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608. Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255. Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968. Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

Alternative Products

产品目录编号

描述

422711

KN-93, Water-Soluble - Calbiochem

显示价格及库存情况

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors

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