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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

420336 Sigma-AldrichKB-R7943 - CAS 182004-65-5 - Calbiochem

KB-R7943 - CAS 182004-65-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2-(2-(4-(4-Nitrobenzyloxy)phenyl)ethyl)isothiourea, methane sulfonate, NMDA Antagonist III

Primary Target: Na+/Ca2+ exchangers

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
182004-65-5	C₁₆H₁₇N₃O₃S • MeSO₃H

价格及供货情况

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Description
Overview	A cell-permeable isothiourea derivative that inhibits the influx/reverse mode of Na⁺/Ca²⁺ exchangers (NCX; IC₅₀ = 4.3 µM, 4.7 µM, and 1.4 µM for NCX1,NCX2, and NCX3, respectively) and directly modulates Na⁺/Mg²⁺ exchange in a Ca²⁺-dependent manner. Reported to offer neuronal and cardioprotection. Also inhibits nicotinic acetylcholine receptors and NMDA receptor channels (IC₅₀ < 10 µM).
Catalogue Number	420336
Brand Family	Calbiochem®
Synonyms	2-(2-(4-(4-Nitrobenzyloxy)phenyl)ethyl)isothiourea, methane sulfonate, NMDA Antagonist III

References
References	Hobai, I.A., and O'Rourke, B. 2004. Expert Opin. Investig. Drugs 13, 653. Uetani, T., et al. 2003. J. Biol. Chem. 278, 47491. Iwamoto, T., et al. 2001. Mol. Pharmacol. 59, 524. Pintado, A.J., et al. 2000. Br. J. Pharmacol. 130, 1893. Sobolevsky, A.I., and Khodorov, B.I. 1999. Neuropharmacology 38, 1235. Iwamoto, T., et al. 1996. J. Biol. Chem. 271, 22391. Watano, T., et al. 1996. Br. J. Pharmacol. 119, 555.

References

Hobai, I.A., and O'Rourke, B. 2004. Expert Opin. Investig. Drugs 13, 653.
Uetani, T., et al. 2003. J. Biol. Chem. 278, 47491.
Iwamoto, T., et al. 2001. Mol. Pharmacol. 59, 524.
Pintado, A.J., et al. 2000. Br. J. Pharmacol. 130, 1893.
Sobolevsky, A.I., and Khodorov, B.I. 1999. Neuropharmacology 38, 1235.
Iwamoto, T., et al. 1996. J. Biol. Chem. 271, 22391.
Watano, T., et al. 1996. Br. J. Pharmacol. 119, 555.

Product Information
CAS number	182004-65-5
ATP Competitive	N
Form	White crystalline solid
Hill Formula	C₁₆H₁₇N₃O₃S • MeSO₃H
Chemical formula	C₁₆H₁₇N₃O₃S • MeSO₃H
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Na+/Ca2+ exchangers
Primary Target IC<sub>50</sub>	4.3 µM, 4.7 µM, and 1.4 µM for NCX1,NCX2, and NCX3, respectively
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
420336-5MGCN	07790788050160

Documentation

KB-R7943 - CAS 182004-65-5 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

KB-R7943 - CAS 182004-65-5 - Calbiochem 分析证书

标题	批号
420336	输入批号

参考

参考信息概述
Hobai, I.A., and O'Rourke, B. 2004. Expert Opin. Investig. Drugs 13, 653. Uetani, T., et al. 2003. J. Biol. Chem. 278, 47491. Iwamoto, T., et al. 2001. Mol. Pharmacol. 59, 524. Pintado, A.J., et al. 2000. Br. J. Pharmacol. 130, 1893. Sobolevsky, A.I., and Khodorov, B.I. 1999. Neuropharmacology 38, 1235. Iwamoto, T., et al. 1996. J. Biol. Chem. 271, 22391. Watano, T., et al. 1996. Br. J. Pharmacol. 119, 555.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	30-July-2008 RFH
Synonyms	2-(2-(4-(4-Nitrobenzyloxy)phenyl)ethyl)isothiourea, methane sulfonate, NMDA Antagonist III
Description	A cell-permeable inhibitor of the influx/reverse mode of the Na⁺/Ca²⁺ exchanger (NCX) (IC₅₀ = 4.3 µM for NCX1, 4.7 µM for NCX2, and 1.4 µM for NCX3). Directly modulates Na⁺/Mg²⁺ exchange in a Ca²⁺-dependent manner. Reported ot offer neuronal and cardio-protection against ischemic injury. Also inhibits nicotinic acetylcholine receptors and NMDA receptor channels (IC₅₀ <10 µM).
Form	White crystalline solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	182004-65-5
Chemical formula	C₁₆H₁₇N₃O₃S • MeSO₃H
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (40 mg/ml) or H₂O (4 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Irritant
References	Hobai, I.A., and O'Rourke, B. 2004. Expert Opin. Investig. Drugs 13, 653. Uetani, T., et al. 2003. J. Biol. Chem. 278, 47491. Iwamoto, T., et al. 2001. Mol. Pharmacol. 59, 524. Pintado, A.J., et al. 2000. Br. J. Pharmacol. 130, 1893. Sobolevsky, A.I., and Khodorov, B.I. 1999. Neuropharmacology 38, 1235. Iwamoto, T., et al. 1996. J. Biol. Chem. 271, 22391. Watano, T., et al. 1996. Br. J. Pharmacol. 119, 555.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Channel Blockers > Sodium Channel Blockers

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