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420129 Sigma-AldrichJNK Inhibitor V - CAS 345987-15-7 - Calbiochem

The JNK Inhibitor V, also referenced under CAS 345987-15-7, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: SAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245

Primary Target: hJNK 1, hJNK 2, hJNK 3

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
345987-15-7	C₂₀H₁₆N₆S

价格及供货情况

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Description
Overview	A cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC₅₀ = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC₅₀ typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration.
Catalogue Number	420129
Brand Family	Calbiochem®
Synonyms	SAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245

References
References	Gaillard, P., et al. 2005. J. Med. Chem. 48, 4596. Carboni, S., et al. 2005. J. Neurochem. 92, 1054. Ferrandi, C., et al. 2004. Br. J. Pharmacol. 142, 953. Carboni, S., et al. 2004. J. Pharm. Exp. Ther. 310, 25.

Product Information
CAS number	345987-15-7
ATP Competitive	Y
Form	Yellow solid
Hill Formula	C₂₀H₁₆N₆S
Chemical formula	C₂₀H₁₆N₆S
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications
Application Comments	Soluble in DMSO, aliquot & store at -20*C; stable for 3 months

Biological Information
Primary Target	hJNK 1, hJNK 2, hJNK 3
Primary Target IC<sub>50</sub>	150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively
Purity	≥95% by HPLC (sum of two isomers)

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
420129-5MGCN	04055977188073

Documentation

JNK Inhibitor V - CAS 345987-15-7 - Calbiochem 分析证书

标题	批号
420129	输入批号

参考

参考信息概述
Gaillard, P., et al. 2005. J. Med. Chem. 48, 4596. Carboni, S., et al. 2005. J. Neurochem. 92, 1054. Ferrandi, C., et al. 2004. Br. J. Pharmacol. 142, 953. Carboni, S., et al. 2004. J. Pharm. Exp. Ther. 310, 25.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	04-January-2010 RFH
Synonyms	SAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245
Description	A cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC₅₀ = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC₅₀ typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	345987-15-7
Chemical formula	C₂₀H₁₆N₆S
Structure formula
Purity	≥95% by HPLC (sum of two isomers)
Solubility	DMSO (10 mg/ml)
Comments	Soluble in DMSO, aliquot & store at -20*C; stable for 3 months
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Harmful
References	Gaillard, P., et al. 2005. J. Med. Chem. 48, 4596. Carboni, S., et al. 2005. J. Neurochem. 92, 1054. Ferrandi, C., et al. 2004. Br. J. Pharmacol. 142, 953. Carboni, S., et al. 2004. J. Pharm. Exp. Ther. 310, 25.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > c-Jun N-Terminal Kinase (JNK/SAP Kinase) Inhibitors

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