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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

420200 Sigma-AldrichJC-1 - CAS 47729-63-5 - Calbiochem

A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential δΨm in cells, tissues, and isolated mitochondria.

JC-1 - CAS 47729-63-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: 5,5ʹ,6,6ʹ-Tetrachloro-1,1ʹ,3,3ʹ-tetraethylbenzimidazolylcarbocyanine Iodide

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
47729-63-5	C₂₅H₂₇Cl₄IN₄

价格及供货情况

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Description
Overview	A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential ΔΨ_m in cells, tissues, and isolated mitochondria. Mitochondrial depolarization is indicated by a decrease in the red/green fluorescence intensity ratio. The potential-sensitive color shift is due to concentration-dependent formation of red fluorescent J-aggregates. Ideal for detection of collapse of ΔΨ_m induced by uncouplers of mitochondrial respiration. JC-1 has also been used in a functional assay of multidrug-resistance cells and in apoptosis-related mitochondrial modifications.
Catalogue Number	420200
Brand Family	Calbiochem®
Synonyms	5,5ʹ,6,6ʹ-Tetrachloro-1,1ʹ,3,3ʹ-tetraethylbenzimidazolylcarbocyanine Iodide

References
References	Mathur, A., et al. 2000. Cardiovasc. Res. 46, 126. Gravance, C.G., et al. 2000. Theriogenology 53, 1691. Chanda, B., and Mathew, M.K. 1999. Biochim Biophys. Acta 1416, 92. Dedov, V.N., and Roufogalis, B.D. 1999. FEBS Lett. 456, 171. Polla, B.S., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6458. White, R.J., and Reynolds, I.J. 1996. J. Neurosci. 16, 5688. Ankacrona, M., et al. 1995. Neuron 15, 961. Reers, M., et al. 1995. Methods Enzymol. 260, 406. Cossarizza, A., et al. 1993. Biochem. Biophys. Res. Commun. 197, 40.

References

Mathur, A., et al. 2000. Cardiovasc. Res. 46, 126.
Gravance, C.G., et al. 2000. Theriogenology 53, 1691.
Chanda, B., and Mathew, M.K. 1999. Biochim Biophys. Acta 1416, 92.
Dedov, V.N., and Roufogalis, B.D. 1999. FEBS Lett. 456, 171.
Polla, B.S., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6458.
White, R.J., and Reynolds, I.J. 1996. J. Neurosci. 16, 5688.
Ankacrona, M., et al. 1995. Neuron 15, 961.
Reers, M., et al. 1995. Methods Enzymol. 260, 406.
Cossarizza, A., et al. 1993. Biochem. Biophys. Res. Commun. 197, 40.

Product Information
CAS number	47729-63-5
ATP Competitive	N
Form	Red-orange solid
Hill Formula	C₂₅H₂₇Cl₄IN₄
Chemical formula	C₂₅H₂₇Cl₄IN₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Used as a ratiometric indicator of mitochondrial potential δΨm in cells, tissues, and isolated mitochondria
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Do not reuse thawed samples.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
420200-5MGCN	04055977210743

Documentation

JC-1 - CAS 47729-63-5 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

JC-1 - CAS 47729-63-5 - Calbiochem 分析证书

标题	批号
420200	输入批号

参考

参考信息概述
Mathur, A., et al. 2000. Cardiovasc. Res. 46, 126. Gravance, C.G., et al. 2000. Theriogenology 53, 1691. Chanda, B., and Mathew, M.K. 1999. Biochim Biophys. Acta 1416, 92. Dedov, V.N., and Roufogalis, B.D. 1999. FEBS Lett. 456, 171. Polla, B.S., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6458. White, R.J., and Reynolds, I.J. 1996. J. Neurosci. 16, 5688. Ankacrona, M., et al. 1995. Neuron 15, 961. Reers, M., et al. 1995. Methods Enzymol. 260, 406. Cossarizza, A., et al. 1993. Biochem. Biophys. Res. Commun. 197, 40.

参考信息概述

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-July-2008 RFH
Synonyms	5,5ʹ,6,6ʹ-Tetrachloro-1,1ʹ,3,3ʹ-tetraethylbenzimidazolylcarbocyanine Iodide
Description	A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential ΔΨ_m in cells, tissues, and isolated mitochondria. It labels mitochondria with high membrane potential orange and mitochondria with low membrane potential green. Mitochondrial depolarization is indicated by a decrease in the red/green fluorescence intensity ratio. Ideal for detection of collapse of ΔΨ_m induced by uncouplers of mitochondrial respiration. The potential-sensitive color shift is due to concentration-dependent formation of red fluorescent J-aggregates. JC-1 has also been used in a functional assay of multidrug-resistance cells and in apoptosis-related mitochondrial modifications.
Form	Red-orange solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	47729-63-5
Chemical formula	C₂₅H₂₇Cl₄IN₄
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Do not reuse thawed samples.
Toxicity	Irritant
References	Mathur, A., et al. 2000. Cardiovasc. Res. 46, 126. Gravance, C.G., et al. 2000. Theriogenology 53, 1691. Chanda, B., and Mathew, M.K. 1999. Biochim Biophys. Acta 1416, 92. Dedov, V.N., and Roufogalis, B.D. 1999. FEBS Lett. 456, 171. Polla, B.S., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6458. White, R.J., and Reynolds, I.J. 1996. J. Neurosci. 16, 5688. Ankacrona, M., et al. 1995. Neuron 15, 961. Reers, M., et al. 1995. Methods Enzymol. 260, 406. Cossarizza, A., et al. 1993. Biochem. Biophys. Res. Commun. 197, 40.

种类

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Dyes, Stains and Probes > Mitochondrial Dyes

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