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420126 Sigma-AldrichJAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem

The JAK3 Inhibitor VI, also referenced under CAS 856436-16-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
技术信息
Data Sheet

Primary Target: JAK-3

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
856436-16-3	C₁₈H₁₃N₃O • MeSO₃H

价格及供货情况

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Description
Overview	A cell-permeable 3′-pyridyl oxindole compound that acts as a potent and reversible inhibitor of JAK3 (IC₅₀ = 27 nM)and displays ~16-fold greater selectivity over JAK2. Binds to the enzyme active site and prevents IL-2-induced cellular phosphorylation of JAK3 and STAT5. Inhibits IL-2-induced cell proliferation (IC₅₀ = 760 and 250 nM for mouse CTLL and human T-cells, respectively) and alleviates oxazolone-induced ear odema in mouse with an efficacy comparable to that of Dexamethasone (Cat. No. 265005).
Catalogue Number	420126
Brand Family	Calbiochem®

References
References	Chen, J., et al. 2006. Bioorg. Med. Chem. Lett. In press. Adams, C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3105.

Product Information
CAS number	856436-16-3
ATP Competitive	N
Form	Yellow solid
Hill Formula	C₁₈H₁₃N₃O • MeSO₃H
Chemical formula	C₁₈H₁₃N₃O • MeSO₃H
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	JAK-3
Primary Target IC<sub>50</sub>	27 nM
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
420126-5MGCN	04055977188042

Documentation

JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem 分析证书

标题	批号
420126	输入批号

参考

参考信息概述
Chen, J., et al. 2006. Bioorg. Med. Chem. Lett. In press. Adams, C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3105.

小册子

标题
Pathways and Biomarkers of JAK/STAT Signaling

技术信息

标题
JAK/STAT Signaling Research Focus

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-January-2010 RFH
Description	A cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3) (IC₅₀ = 27 nM). Reported to bind to the enzyme active site and prevent IL-2-induced phosphorylation of JAK3 and STAT5. Also reported to inhibit IL-2-induced cell proliferation (IC₅₀ = 760 nM for murine CTLL cells and 250 nM for human T-cells). Shown to alleviate oxazolone-induced ear edema in mice with an efficacy comparable to Dexamethasone (Cat. No. 265005) and displays ~16-fold greater selectivity over JAK2.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	856436-16-3
Chemical formula	C₁₈H₁₃N₃O • MeSO₃H
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (5 mg/ml) or H₂O (1 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Chen, J., et al. 2006. Bioorg. Med. Chem. Lett. In press. Adams, C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3105.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > JAK Inhibitors

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