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420132 JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem

概述

Replacement Information

重要规格表

CAS #Empirical Formula
1837-91-8C₆H₆Br₆

价格及供货情况

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420132-25MGCN
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      塑胶安瓿;塑胶针药瓶 25 mg
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      Description
      OverviewA cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.
      Catalogue Number420132
      Brand Family Calbiochem®
      Synonyms1,2,3,4,5,6-Hexabromocyclohexane
      References
      ReferencesSandberg, E.M., et al. 2005. J. Med. Chem. 48, 2526.
      Product Information
      CAS number1837-91-8
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₆H₆Br₆
      Chemical formulaC₆H₆Br₆
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetJAK2 autophosphorylation
      Purity≥ 97% by GC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      420132-25MGCN 04055977188103

      Documentation

      JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem 分析证书

      标题批号
      420132

      参考

      参考信息概述
      Sandberg, E.M., et al. 2005. J. Med. Chem. 48, 2526.

      技术信息

      标题
      JAK/STAT Signaling Research Focus
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-December-2010 RFH
      Synonyms1,2,3,4,5,6-Hexabromocyclohexane
      DescriptionA cell-permeable, specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2 that interacts with a solvent-accessible pocket near the activation loop of JAK2. Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1837-91-8
      Chemical formulaC₆H₆Br₆
      Structure formulaStructure formula
      Purity≥ 97% by GC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSandberg, E.M., et al. 2005. J. Med. Chem. 48, 2526.