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420099 Sigma-AldrichJAK Inhibitor I - CAS 457081-03-7 - Calbiochem

JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC₅₀ = 15 nM), JAK2 (IC₅₀ = 1 nM), JAK3 (K_i = 5 nM) and Tyk2 (IC₅₀ = 1 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
技术信息
数据表
Data Sheet
Citations

同义词: 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, Pyridone 6, P6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X

Primary Target: murine JAK1

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
457081-03-7	C₁₈H₁₆FN₃O

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
420099-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	A potent, reversible, cell-permeable, and ATP-competitive inhibitor of Janus protein tyrosine kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC₅₀ = 15 nM for murine JAK1), JAK2 (IC₅₀ = 1 nM), JAK3 (K_i = 5 nM), and Tyk2 (IC₅₀ = 1 nM). Inhibits other kinases at much higher concentrations. Shown to inhibit IL2- and IL4-dependent proliferation of CTLL cells and block the phosphorylation of STAT5; and further induce growth inhibition of multiple myeloma cells expressing activated JAKs and STAT3, unlike AG 490 (Cat. No. 658401). A 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420097) in DMSO is also available.
Catalogue Number	420099
Brand Family	Calbiochem®
Synonyms	2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, Pyridone 6, P6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X

References
References	Pedranzini, L., et al. 2006. Cancer Res. 66, 9714. Lucet, I.S., et al. 2005. Blood 107, 176. Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219.

Product Information
CAS number	457081-03-7
ATP Competitive	Y
Form	Off-white solid
Hill Formula	C₁₈H₁₆FN₃O
Chemical formula	C₁₈H₁₆FN₃O
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	murine JAK1
Primary Target IC<sub>50</sub>	15 nM against murine JAK1; 1 nM against JAK2; 1 nM against Tyk2
Primary Target K<sub>i</sub>	5 nM against JAK3
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
420099-1MGCN	04055977187878
420099-500UGCN	04055977187885

Documentation

JAK Inhibitor I - CAS 457081-03-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

JAK Inhibitor I - CAS 457081-03-7 - Calbiochem 分析证书

标题	批号
420099	输入批号

参考

参考信息概述
Pedranzini, L., et al. 2006. Cancer Res. 66, 9714. Lucet, I.S., et al. 2005. Blood 107, 176. Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219.

小册子

标题
An Introduction to Inhibitors and Their Biological Applications - 1st Edition
Pathways and Biomarkers of JAK/STAT Signaling

技术信息

标题
JAK/STAT Signaling Research Focus

数据表

标题
Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation

引用

标题

Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-January-2010 RFH
Synonyms	2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, Pyridone 6, P6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
Description	A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Janus protein tyrosine kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC₅₀ = 15 nM for murine JAK1), JAK2 (IC₅₀ = 1 nM), JAK3 (K_i = 5 nM), and Tyk2 (IC₅₀ = 1 nM). Inhibits other kinases at much higher concentrations. Shown to inhibit IL2- and IL4-dependent proliferation of CTLL cells and block the phosphorylation of STAT5, and further induce growth inhibition of multiple myeloma cells expressing activated JAKs and STAT3, unlike AG 490 (Cat. No. 658401).
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	457081-03-7
Chemical formula	C₁₈H₁₆FN₃O
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Pedranzini, L., et al. 2006. Cancer Res. 66, 9714. Lucet, I.S., et al. 2005. Blood 107, 176. Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219.
Citation	Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > JAK Inhibitors

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420099 Sigma-AldrichJAK Inhibitor I - CAS 457081-03-7 - Calbiochem

JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC₅₀ = 15 nM), JAK2 (IC₅₀ = 1 nM), JAK3 (K_i = 5 nM) and Tyk2 (IC₅₀ = 1 nM).

同义词: 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, Pyridone 6, P6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X

Recommended Products

概述

重要规格表

价格及供货情况

Documentation

JAK Inhibitor I - CAS 457081-03-7 - Calbiochem MSDS

JAK Inhibitor I - CAS 457081-03-7 - Calbiochem 分析证书

参考

小册子

技术信息

数据表

引用

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JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC₅₀ = 15 nM), JAK2 (IC₅₀ = 1 nM), JAK3 (Ki = 5 nM) and Tyk2 (IC₅₀ = 1 nM).

同义词: 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, Pyridone 6, P6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X

Recommended Products

重要规格表

价格及供货情况

JAK Inhibitor I - CAS 457081-03-7 - Calbiochem MSDS

JAK Inhibitor I - CAS 457081-03-7 - Calbiochem 分析证书

参考

小册子

技术信息

数据表

引用

种类

最近查看的内容

JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC₅₀ = 15 nM), JAK2 (IC₅₀ = 1 nM), JAK3 (K_i = 5 nM) and Tyk2 (IC₅₀ = 1 nM).