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A water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC50 of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Chan, C. S. et al. 2007. Nature.447, 1081. Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci.45, 708. Koschak, A. et al. 2003. J. Neurosci./i> 23, 6041. Koschak, A. et al. 2001. J. Biol Chem276, 22100.
Chan, C. S. et al. 2007. Nature.447, 1081. Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci.45, 708. Koschak, A. et al. 2003. J. Neurosci./i> 23, 6041. Koschak, A. et al. 2001. J. Biol Chem276, 22100.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC50 of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.
Form
Yellow solid
CAS number
75695-93-1
Chemical formula
C₁₉H₂₁N₃O₅
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (100 mM) or Ethanol (50 mM)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Chan, C. S. et al. 2007. Nature.447, 1081. Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci.45, 708. Koschak, A. et al. 2003. J. Neurosci./i> 23, 6041. Koschak, A. et al. 2001. J. Biol Chem276, 22100.
