681679 Sigma-AldrichIron Chelator IV, 21H7 - Calbiochem
The Iron Chelator IV, 21H7 controls the biological activity of iron-regulated enzymes. This small molecule/inhibitor is primarily used for Cancer applications.
More>> The Iron Chelator IV, 21H7 controls the biological activity of iron-regulated enzymes. This small molecule/inhibitor is primarily used for Cancer applications. Less<<Iron Chelator IV, 21H7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: 6-Bromo-Nʹ-(2-hydroxybenzylidene)-2-methylquinoline-4-carbohydrazide
Recommended Products
概述
| Replacement Information |
|---|
重要规格表
| Empirical Formula |
|---|
| C₁₈H₁₄BrN₃O₂ |
价格及供货情况
| 产品目录编号 | 库存情况 | 包装 | 数量 / 包装 | 价格 | 数量 | |
|---|---|---|---|---|---|---|
| 681679-10MGCN |
|
玻璃瓶 | 10 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable salicylaldehyde-acylhydrazone iron chelator that is 20-times more efficient than DFO/desferrioxamine (Cat. No. 252750) in depleting intracellular iron in colon cancer SW480 cells. Iron chelators exert their biological activities by affecting iron-regulated enzymes and singaling events, including HIF1α transcription activation due to inhibition of PHD- (prolyl hydroxylase) mediated HIF1α degradation, as well as altered mRNA translations due to enhanced IRP (Iron Regulatory Protein) IREs (Iron Response Elements) binding. Cellular iron depletion is also reported to inhibit the growths of colorectal adenocarcinoma cultures, DLD-1 (IC50 = 0.6 and 2.9 µM, respectively, by 21H7 and DFO) and SW480 (IC50 = 1.0 and 3.8 µM, respectively, by 21H7 and DFO), as a result of Wnt signaling pathway blockage (Effective conc. = 5 µM 21H7 or 100 µM DFO). |
| Catalogue Number | 681679 |
| Brand Family | Calbiochem® |
| Synonyms | 6-Bromo-Nʹ-(2-hydroxybenzylidene)-2-methylquinoline-4-carbohydrazide |
| References | |
|---|---|
| References | Song, S., et al. 2011. Cancer Res. 71, 7628. |
| Product Information | |
|---|---|
| Form | Off-white solid |
| Hill Formula | C₁₈H₁₄BrN₃O₂ |
| Chemical formula | C₁₈H₁₄BrN₃O₂ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Purity | ≥97% by HPLC |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| 产品目录编号 | GTIN |
| 681679-10MGCN | 04055977225266 |
Documentation
Iron Chelator IV, 21H7 - Calbiochem MSDS
| 职位 |
|---|
Iron Chelator IV, 21H7 - Calbiochem 分析证书
| 标题 | 批号 |
|---|---|
| 681679 |
参考
| 参考信息概述 |
|---|
| Song, S., et al. 2011. Cancer Res. 71, 7628. |
| 数据表 | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|